Amardeep Manikrao Vaygavkar¹ and Sangita Sanjay Makone^2*

¹Research Scholar, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India
²Professor, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India

*Corresponding Author: Sangita Sanjay Makone, Professor, School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Vishnupuri, Nanded-431606, Maharashtra, India.

Received: October 13, 2026; Published: October 28, 2026

Abstract

Through a one-pot multi-component condensation reaction of aromatic aldehydes, anilines, and β-ketoester in the presence of Zn(OAc)2•2H2O as a Lewis acidic catalyst in toluene at 80 oC, we have successfully developed an efficient and environmentally friendly synthesis of a series of 1,2,5,6-tetrahydropyridine-3-carboxylate derivatives. High catalytic activity, decent yields, ease of use, a broad range of functional group tolerance, and column-free approach are some of the benefits of this low-cost, ecologically friendly protocol.

Keywords: Aldehydes; Anilines; β-keto Esters; Zn(OAc)2•2H2O; Tetrahydropyridines; Lewis Acid; Multi-Component Reactions

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Citation

Citation: Amardeep Manikrao Vaygavkar and Sangita Sanjay Makone. “Zinc Acetate as an Efficient Catalyst for the Synthesis of Multi substituted Piperi- dines". Acta Scientific Pharmaceutical Sciences 10.6 (2026): 57-64.

Copyright

Copyright: © 2026 Amardeep Manikrao Vaygavkar and Sangita Sanjay Makone. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.