Yamini Malhotra*

Researcher - Author, Maharashtra, India

*Corresponding Author: Yamini Malhotra, Researcher - Author, Maharashtra, India.

Received: April 10, 2026 Published: May 04, 2026

Abstract

Type 2 diabetes mellitus (T2DM) has historically been conceptualized as a chronic, progressive disease. However, converging evidence from clinical trials and metabolic research indicates that remission is achievable under specific physiological conditions, particularly through intensive dietary intervention and weight loss. This paper advances the Metabolic Remission Theorem (MRT), a formal, testable framework integrating dietary quality, caloric restriction, weight loss, insulin resistance, and metabolic flexibility into a unified causal model. Drawing on the Twin Cycle Hypothesis, the DiRECT trial, and recent guidelines with articulate axioms- derive the MRT, and specify falsifiable hypotheses. A longitudinal structural equation modeling (SEM) design is proposed, including power analysis, measurement strategy, and model fit criteria. The framework has implications for clinical protocols, public health policy, and future mechanistic research.

Keywords: Type 2 Diabetes; Remission; Diet; Insulin Resistance; Metabolic Flexibility; Nutrition Therapy

References

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Citation

Citation: Yamini Malhotra. “A Quantitative Model of Metabolic Remission: Diet-Driven Pathways in Type 2 Diabetes". Acta Scientific Pharmaceutical Sciences 10.5 (2026): 01-13.

Copyright

Copyright: © 2026 Yamini Malhotra. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.