Salvador Nadal Domingo*, Silvia Mir Palomo and Desamparados Domingo Tortajada

Benilloba´s Pharmacy, Spain

*Corresponding Author: Salvador Nadal Domingo, Benilloba´s Pharmacy, Spain.

Received: February 25, 2026 Published: March 26, 2026

Abstract

Objective: To analyze the published evidence on the impact of statins in the prevention and progression of Alzheimer's disease, focusing on mechanisms, clinical efficacy, and population subgroups through a systematic review following PRISMA methodology.

Design: Systematic review.

Data Sources: PubMed, Embase, Web of Science, and Scopus databases were searched for studies published from January 2020 to June 2025. Priority was given to systematic reviews, meta-analyses, cohort studies, clinical trials, and population-based studies in humans, published in English and Spanish.

Study Selection: Relevant human studies focused on statins and Alzheimer's disease or dementia were included. After applying selection and exclusion criteria, 14 studies were included and 70 were excluded after full-text review.

Data Extraction: A rigorous methodological quality assessment was conducted according to international guidelines. Variables collected included study type, population, type and dosage of statins, treatment duration, main outcomes, and genetic factors.

Results: Most studies show that statin use is associated with an 18% to 32% reduction in dementia risk, including Alzheimer's disease. The protective effect is more evident with lipophilic statins and in specific genetic subgroups. However, heterogeneity and methodological limitations exist.

Conclusions: Statins may play a relevant role, especially in personalized approaches, but further clinical trials and pharmacogenomic studies are necessary to define their specific utility and practical applications.

Keywords: Statins; Alzheimer's Disease; Dementia

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Citation

Citation: Salvador Nadal Domingo., et al. “The Role of Statins and Alzheimer's Disease: Systematic Review of Recent Human Studies". Acta Scientific Pharmaceutical Sciences 10.4 (2026): 20-24.

Copyright

Copyright: © 2026 Salvador Nadal Domingo., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.