Omada Adams Akogwu¹*, Okpe John Mathias², Abalaka Daniel Hassan³, Oka Samson Ayodeji¹, Odiba John Chubiyojo⁴, Ibrahim Gladys Eleojo⁵, Kokori Bajeh Tijani⁶ and Obaje Gideon Sunday¹

¹Department of Medical Biochemistry, Prince Abubakar Audu University, Anyigba,
Nigeria
²Department of Biochemistry, Federal University of health Sciences, Otukpo, Nige-
ria
³Department of Science Laboratory Technology, Kogi State Polytechnic, Lokoja,
Nigeria
⁴Department of Biochemistry, Salem University, Lokoja, Nigeria
⁵Department of Biochemistry, Prince Abubakar Audu University, Anyigba, Nigeria
⁶Department of Pharmacology, Prince Abubakar Audu University, Anyigba, Nigeria

*Corresponding Author: Omada Adams Akogwu, Department of Medical Biochem- istry, Prince Abubakar Audu University, Anyigba, Nigeria.

Received: February 24, 2026 Published: March 12, 2026

Abstract

Maintaining biological equilibrium and ensuring optimal physiological performance requires a precise balance between the production of free radicals and available antioxidant concentrations. This balance is typically sustained when endogenous defense mechanisms specifically glutathione, catalase, and superoxide dismutase regulate cellular free radicals below a critical threshold. However, should radical generation surpass the capacity of this internal scavenging network, the integration of natural exogenous antioxidants via dietary intake becomes vital for mitigating and forestalling oxidative damage. Persistent oxidative stress leads to cellular degradation, playing a fundamental role in the clinical development of various chronic-degenerative and metabolic diseases. Because oxidative stress stems from a disparity between pro-oxidant forces and the body’s antioxidant defense systems. Utilizing supplemental antioxidants to reinforce endogenous antioxidant defenses is a recognized therapeutic approach. This strategy is particularly effective in addressing metabolic disorders such as inflammatory states, atherosclerosis, type 2 diabetes, and metabolic syndrome, as well as the biological progression of aging.

Keywords: Aantioxidant; Atherosclerosis; Free Radical; Metabolic Syndrome; Oxidative Stress

References

1. Jomova K., et al. "Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging”. Archives of Toxicology9 (2023): 2499-2574.
2. Di Carlo E. and Carlo S. "Oxidative Stress and Age-Related Tumors”. Antioxidants9 (2024): 1109.
3. Hong Y., et al. "Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution”. Antioxidants 3 (2024): 312.
4. Bouayed J and Torsten B. "Exogenous Antioxidants-, Double-Edged Swords in Cellular Redox State: Health Beneficial Effects at Physiologic Doses versus Deleterious Effects as Antinutrients at High Doses”. Oxidative Medicine and Cellular Longevity 4 (2010): 228-237.
5. Pourmontaseri H., et al. "Exploring the Application of Dietary Antioxidant Index for Disease Risk Assessment: A Comprehensive Review”. Frontiers in Nutrition 11 (2025).
6. Martemucci G., et al. "Comprehensive Strategies for Metabolic Syndrome: How Nutrition, Dietary Polyphenols, Physical Activity, and Lifestyle Modifications Address Diabesity, Cardiovascular Diseases, and Neurodegenerative Conditions”. Metabolites6 (2024): 327.
7. Sharifi-Rad M., et al. "Lifestyle, Oxidative Stress, and Antioxidants: Back and Forth in the Pathophysiology of Chronic Diseases”. Frontiers in Physiology 11 (2020): 694.
8. Martemucci G., et al. "Free Radical Properties, Source and Targets, Antioxidant Consumption and Health”. Oxygen 2 (2022): 48-78.
9. Hong Y., et al. "Reactive Oxygen Species Signaling and Oxidative Stress: Transcriptional Regulation and Evolution”. Antioxidants 3 (2024): 312.
10. Corpas J and Juan B. "Reactive Sulfur Species (RSS): Possible New Players in the Oxidative Metabolism of Plant Peroxisomes”. Frontiers in Plant Science 6 (2015): 116.
11. Adwas A., et al. "Oxidative Stress and Antioxidant Mechanisms in Human Body”. Journal of Applied Biotechnology and Bioengineering1 (2019): 43-47.
12. Jomova K., et al. "Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging”. Archives of Toxicology9 (2023): 2499-574.
13. Nimse B and Dilipkumar P. "Free Radicals, Natural Antioxidants, and Their Reaction Mechanisms”. The Royal Society of Chemistry 35 (2015): 27986-8006.
14. Brewer S. "Natural Antioxidants: Sources, Compounds, Mechanisms of Action, and Potential Applications”. Comprehensive Reviews in Food Science and Food Safety 4 (2011): 221-46.
15. Ighodaro M and Akinloye O. "First Line Defence Antioxidants-Superoxide Dismutase (SOD), Catalase (CAT) and Glutathione Peroxidase (GPX): Their Fundamental Role in the Entire Antioxidant Defence Grid”. Alexandria Journal of Medicine4 (2018): 287-293.
16. Prior L., et al. "Standardized Methods for the Determination of Antioxidant Capacity and Phenolics in Foods and Dietary Supplements”. Journal of Agricultural and Food Chemistry10 (2005) 4290-4302.
17. Salvador A and Michael S. "Quantitative Evolutionary Design of Glucose 6-Phosphate Dehydrogenase Expression in Human Erythrocytes”. Proceedings of the National Academy of Sciences (PNAS)8 (2026): e2335687100.
18. Dietrich-Muszalska A., et al. "Redox Homeostasis and Oxidative Stress in Human Metabolism and Disease: 2^nd Edition”. Antioxidants1 (2026): 10191.
19. Del Rio D., et al. "Dietary (Poly) phenolic in Human Health: Structures, Bioavailability, and Evidence of Protective Effects against Chronic Diseases”. Antioxidants and Redox Signaling14 (2013): 1818-1892.
20. Ozcan T., et al. "Phenolics in Human Health”. International Journal of Chemical Engineering and Applications 5 (2014): 393-396.
21. Bondar A., et al. "From Bench to Bedside: Therapeutic Potential of Natural Antioxidants in Diabetic Neuropathy”. Frontiers in Cell and Developmental Biology 13 (2025): 1631678.
22. Thapa R., et al. "Polyphenols: Nature's Gift as Dietary Phytoconstituents against Different Human Ailments”. Nepal Journal of Biotechnology1 (2019): 103 -112.
23. Perakis K., et al. "The Role of Plant-Derived Bioactive Compounds in Mitigating Oxidative Stress”. International Journal of Molecular Sciences1 (2025): 12785908.
24. Zeng X. and Yang Y. "Linking Oxidative Stress Biomarkers to Disease Progression and Antioxidant Therapy in Hypertension and Diabetes Mellitus”. Frontiers in Molecular Biosciences 11 (2024): 1611842.
25. Yoshikawa T and Feng Y. "Oxidative Stress and Bio-Regulation”. International Journal of Molecular Sciences6 (2024): 3360.
26. Caturano A., et al. "Oxidative Stress and Cardiovascular Complications in Type 2 Diabetes: From Pathophysiology to Lifestyle Modifications”. Antioxidants1 (2025): 72.
27. Chen X., et al. "Oxidative Stress in Diabetes Mellitus and Its Complications: From Pathophysiology to Therapeutic Strategies”. Chinese Medical Journal1 (2024) 15-27.
28. Rajendiran D., et al. "A Review on Role of Antioxidants in Diabetes”. Asian Journal of Pharmaceutical and Clinical Research 2 (2018): 48-53.
29. Kim Y., et al. "Polyphenols and Glycemic Control”. Nutrients1 (2016): 17.
30. Malekmohammad K., et al. "Antioxidants and Atherosclerosis: Mechanistic Aspects”. Biomolecules 8 (2019): 301.
31. Chiva-Blanch G and Lina B. "Effects of Polyphenol Intake on Metabolic Syndrome: Current Evidences from Human Trials”. Oxidative Medicine and Cellular Longevity (2017): 1-18.
32. Karam S., et al. "Oxidative Stress and Inflammation as Central Mediators of Atrial Fibrillation in Obesity and Diabetes”. Cardiovascular Diabetology 1 (2017): 120-129.
33. Pfeuffer M., et al. "Effect of Quercetin on Traits of the Metabolic Syndrome, Endothelial Function and Inflammation in Men with Different APOE Isoforms”. Nutrition, Metabolism and Cardiovascular Diseases 5 (2013): 403-09.
34. Houldsworth A. "Role of Oxidative Stress in Neurodegenerative Disorders: A Review of Reactive Oxygen Species and Prevention by Antioxidants”. Brain Communications 1 (2023): fcad356.
35. Mendez-del M., et al. "Effect of Resveratrol Administration on Metabolic Syndrome, Insulin Sensitivity, and Insulin Secretion”. Metabolic Syndrome and Related Disorders 10 (2014): 497-501.
36. Reinhart M., et al. "The Impact of Garlic on Lipid Parameters: A Systematic Review and Meta-Analysis”. Nutrition Research Reviews 1 (2009): 39-48.
37. Hodgson M., et al. "Effects of Vitamin E, Vitamin C and Polyphenols on the Rate of Blood Pressure Variation: Results of Two Randomized Controlled Trials”. British Journal of Nutrition 9 (2014): 1551-1561.
38. Gregorio M., et al. "The Potential Role of Antioxidants in Metabolic Syndrome”. Current Pharmaceutical Design 7 (2016): 859-869.
39. Wendt J., et al. "Are Supra-Physiological Plant-Based Antioxidants Ready for the Clinic? A Scoping Review of Hormetic Influences Driving Positive Clinical Outcomes”. Global Advances in Integrative Medicine and Health 13 (2024).
40. Didier J., et al. "Antioxidant and Anti-tumor Effects of Dietary Vitamins A, C, and E”. Antioxidants3 (2023): 632.
41. Li S., et al. "Potential Harms of Supplementation with High Doses of Antioxidants in Athletes”. Journal of Exercise Science and Fitness 4 (2022): 269-275.
42. Baltusnikiene A., et al. "Beneficial and Adverse Effects of Vitamin E on the Kidney”. Frontiers in Physiology 14 (2023).
43. "Associations between Vitamins Intake and Risk of Cancer in United States Adults: 2003 to 2016 National Health and Nutrition Examination Survey”. Frontiers in Nutrition (2025).

Citation

Citation: Omada Adams Akogwu., et al. “Antioxidants and their Role against Free Radicals-Mediated Metabolic Disorders: A Review". Acta Scientific Pharmaceutical Sciences 10.4 (2026): 04-13.

Copyright

Copyright: © 2026 Omada Adams Akogwu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.