Jasmine Kaur Randhawa¹*, Kusha Sharma² and Neeraj Lata¹

¹Pharmacy Officer, Civil Hospital, Tarn Taran, India
²Pharmacy Officer, Civil Hospital, Pathankot, India

*Corresponding Author: Jasmine Kaur Randhawa, Pharmacy Officer, Civil Hospital, Tarn Taran, India.

Received: November 14, 2025; Published: November 29, 2025

Abstract

Psoriasis, an autoimmune disorder, is characterized by chronic skin inflammatory condition. It is associated with overproduction of skin cells triggered by overactivity of immune system response. The hyperactivity of immune system leads to proliferation of skin cells in response causing formation of thick, red scaly patches that later develop into silvery scales. This disease effects various body parts like scalp, elbows, knees and lower back. This disease is accompanied with various other comorbidities such as arthritis, cardiovascular diseases, psychological disturbances etc. Thus it is a major health risk challenge worldwide. Many therapies are currently available to control and heal the symptoms of psoriasis that includes corticosteroids, immunosuppressants, phototherapy, psoralens, coconut oil etc. The systemic and oral therapies poses many serious side effects so topical therapy is a better alternative for the psoriasis treatment. One of these, microemulsions are novel drug delivery system that reduce the side effects of other route therapies. Also, it offers the advantage of enhanced permeation through the skin and reduced entrapped drug size thus having increased surface area and hence enhanced activity on the damaged skin cells. Mycophenolate Mofetil, an immunosuppressant agent, is a prodrug that metabolises to mycophenolic acid in- vivo. It acts through suppression of specific enzyme biosynthesis that impacts the proliferation of T&B lymphocytes, the key players in psoriasis. Vitamin E TPGS-1000, a novel non- ionic and biocompatible surfactant can be used to formulate microemulsion incorporating Mycophenolate Mofetil as a therapeutic drug. It is a very effective surfactant that decreases the interfacial tension between the aqueous and oily phases and hence increase their mutual solubility. It also acts through micellar solubilization above its critical micelle concentration. It is a penetration enhancer, antioxidant owing to vitamin E molecular group, emulsifying agent due to the presence of both hydrophilic and lipophilic molecular structures present, anti – inflammatory properties which can subsequently reduce the typical symptoms of psoriasis. The present review aims at the possibility of formulation design of TPGS-1000 based microemulsion of Mycophenolate Mofetil for successful treatment of psoriasis.

Keywords: Psoriasis; Mycophenolate Mofetil; Vitamin E-TPGS; Inflammation; T Lymphocytes

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Citation

Citation: Jasmine Kaur Randhawa.,et al. “TPGS-1000 Enriched Microemulsion Design as a Novel Approach for the Delivery of Mycophenolate Mofetil in the Treatment of Psoriasis and it's Future Research Prospective". Acta Scientific Pharmaceutical Sciences 9.12 (2025): 48-56.

Copyright

Copyright: © 2025 Jasmine Kaur Randhawa., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.