Gamze Ozgun^1,2, Fatih Alaylı³, Fatih Donmez⁴ and Husniye Kayalar³*

¹Manisa Provincial Health Directorate Merkezefendi State Hospital, Manisa, Turkey
²Ege University, Graduate School of Health Sciences, Izmir, Turkey
³Ege University Faculty of Pharmacy Department of Pharmacognosy, Bornova, Izmir, Turkey
⁴Van Yuzuncu Yil University, Faculty of Pharmacy, Department of Biochemistry, Van, Turkey

*Corresponding Author: Husniye Kayalar, Ege University Faculty of Pharmacy Department of Pharmacognosy, Bornova, Izmir, Turkey.

Received: November 03, 2025; Published: November 28, 2025

Abstract

Introduction: Heracleum persicum, also known as "Golpar" or "suh otu" in Turkey, has long been used as a spice and to treat a variety of illnesses. H. persicum is known to contain volatile substances, terpenoids, triterpenes, furanocoumarins, flavonoids, and alkaloids. This study aimed to determine the antioxidant potential with total phenolics and flavonoids contents.

Methods: The ethyl acetate, n-hexane, ethanol, and diethylether extracts of the aerial parts were prepared by maceration. The antioxidant capacity of the extracts were analyzed with DPPH radical scavenging activity. Folin-Ciocalteu and Aluminum chloride methods were used to determine the total phenolics and flavonoid contents.

Results: The highest extraction yield was obtained from ethanol extract wheras the ethylacetate extract with the highest antioxidant potential was found to inhibit DPPH radical by 6.873 ± 0.123 %. The highest phenolic (247,82 ± 0,0176 mg GAE % dw) and flavonoid contents (155,82 ± 0,0022 mg QE % dw) were found in the ethanolic extract of Heracleum persicum.

Conclusions: The antioxidant activity, the total phenolics and flavonoid contents of extracts prepared from aerial parts of H. persicum, using solvents with different polarities is comparatively analyzed for the first time in this study. The findings suggest its use in food supplements, both as a medicinal plant and as an additive, due to its antioxidant properties and rich phenolic and flavonoid contents.

Keywords: Antioxidant; Heracleum persicum; Total Phenolics; Flavonoid

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Citation

Citation: Husniye Kayalar., et al. “Antioxidant Potential of Heracleum Persicum Desf. Ex. Fisch. Extracts". Acta Scientific Pharmaceutical Sciences 9.12 (2025): 28-35.

Copyright

Copyright: © 2025 Husniye Kayalar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.