Department of Pharmaceutical Chemistry, School of Pharmacy, Netaji Subhas University, India

*Corresponding Author: Suraj Kumar Sharma, Department of Pharmaceutical Chemistry, School of Pharmacy, Netaji Subhas University, India.

Received: March 06, 2025; Published: March 27, 2025

In recent years, it has been widely acknowledged that the frequency of negative responses to medications in patients rises with advancing age (1–3). Nevertheless, the causes for the heightened occurrence are sometimes unclear and frequently vary depending on the medication. The rise in occurrence occasionally seems connected to physiological modifications affecting tissue action site sensitivity. In contrast, in other instances, it seems linked to alterations in pharmacokinetic parameters that control the drug concentration at the action sites. The higher occurrence is probably due to a combination of age-related changes, and it is often unclear which type of change is more significant in a specific case.

Keywords: Liver; Microsome; Total Body Clearance; Blood Flow Rate; Intrinsic Clearance Unbind Drug

References

1. Wilde M., et al. “Metabolic Pathways and Potencies of New Fentanyl Analogs”. Frontiers in Pharmacology 10 (2019): 238.
2. Rizzieri D., et al. “Metabolic alterations and the potential for targeting metabolic pathways in treating multiple myeloma”. Journal of Cancer Metastasis and Treatment 5 (2019).
3. Garza AZ., et al. StatPearls [Internet]. StatPearls Publishing; Treasure Island (FL): Jul 4, 2023. Drug Elimination (2023).
4. Pascale A., et al. “The role of gut microbiota in obesity, diabetes mellitus, and effect of metformin: new insights into old diseases”. Current Opinion on Pharmacology 49 (2019): 1-5.
5. Azzam AAH., et al. “Hot topics in opioid pharmacology: mixed and biased opioids”. British Journal of Anaesthesia 6 (2019): e136-e145.
6. Boyland E and Chasseaud LF. “The role of glutathione and glutathione S-transferases in mercapturic acid biosynthesis”. Advances in Enzymology and Related Areas of Molecular Biology 32 (1969): 173-219.
7. Bernhardt R. “Cytochromes P450 as versatile biocatalysts”. Journal of Biotechnology1 (2006): 128-145.
8. Commandeur JN., et al. “Enzymes and transport systems are involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics”. Pharmacology Review 2 (1995): 271-330.
9. Meyer UA and Zanger UM. “Molecular mechanisms of genetic polymorphisms of drug metabolism”. Annual Review of Pharmacology and Toxicology 37 (1997): 269-296.
10. Guengerich FP. “Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity”. Chemical Research in Toxicology6 (2001): 611-650.
11. Bolton AE., et al. “Effect of rifampicin on the pharmacokinetics of imatinib mesylate (Gleevec, STI571) in healthy subjects”. Cancer Chemotherapy and Pharmacology2 (2004): 102-106.
12. Colizzi M., et al. “Descriptive Psychopathology of the Acute Effects of Intravenous Delta-9-Tetrahydrocannabinol Administration in Humans”. Brain Science4 (2019).
13. Patilea-Vrana GI., et al. “Hepatic Enzymes Relevant to the Disposition of (-)-∆9-Tetrahydrocannabinol (THC) and Its Psychoactive Metabolite, 11-OH-THC”. Drug Metabolism and Disposition3 (2019): 249-256.
14. Baldo BA. “Opioid analgesic drugs and serotonin toxicity (syndrome): mechanisms, animal models, and links to clinical effects”. Archives of Toxicology8 (2018): 2457-2473.
15. Kotlinska-Lemieszek A., et al. “Clinically Significant Drug-Drug Interactions Involving Medications Used for Symptom Control in Patients With Advanced Malignant Disease: A Systematic Review”. Journal of Pain Symptom Management5 (2019): 989-998.e1.
16. Sirimsi MM., et al. “Scoping review to identify strategies and interventions improving interprofessional collaboration and integration in primary care”. BMJ Open10 (2022): e062111.
17. Bosch B and Mansell H. “Interprofessional collaboration in health care: Lessons to be learned from competitive sports”. Canadian Pharmacists Journal (Ott)4 (2015): 176-179.

Citation

Citation: Suraj Kumar Sharma., et al. “Analysis of Drug Metabolism". Acta Scientific Pharmaceutical Sciences 9.4 (2025): 56-61.

Copyright

Copyright: © 2025 Suraj Kumar Sharma., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.