Devnath Netam¹, Tanuj Pandey¹, Vikalp Singh¹, Rishu Kumar¹, Anjali Sahu¹ and Gyanesh Kumar Sahu²*

¹Rungta Institute of Pharmaceutical Sciences Kohka, Bhilai, India
²Rungta Institute of Pharmaceutical Sciences and Research Kohka, Bhilai, India

*Corresponding Author: Gyanesh Kumar Sahu, Professor and Dean, Rungta Institute of Pharmaceutical Sciences and Research, Kohka, Kurud, Bhilai, India.

Received: March 05, 2025; Published: March 12, 2025

Abstract

Abstract

Lavender (Lavandula angustifolia) essential oil has long been recognized for its antimicrobial properties, which make it a promising candidate for topical formulations. This study investigates the formulation of a lavender-based antimicrobial ointment, evaluating its effectiveness against common pathogenic microorganisms, including Staphylococcus aureus, Escherichia coli, and Candida albicans. The lavender essential oil, known for its broad-spectrum antimicrobial activity, was incorporated into an ointment base composed of natural emulsifiers and moisturizers. The antimicrobial activity of the ointment was assessed using standard agar diffusion methods and minimum inhibitory concentration (MIC) tests. Results indicated that the lavender-based ointment exhibited significant antimicrobial activity against both bacterial and fungal strains, with notable inhibition zones observed in all tested microorganisms. The ointment also showed minimal skin irritation in preliminary dermatological assessments, suggesting its suitability for use in topical treatments. These findings support the potential of lavender essential oil as a natural alternative for the formulation of antimicrobial ointments, providing a safe and effective remedy for managing skin infections and other dermatological conditions. Further clinical studies are recommended to confirm its efficacy and safety for long-term use.

Keywords: Anti-microbial; Dermatological; Potential

References

1. Bijilsma JW., et al. “Osteoarthritis: An update with relevance for clinical practice”. Lancet 377 (2011): 2115-2126.
2. McAlindon T and Dieppe P. “The medical management of osteoarthritis of the knee: An inflammatory disease?” British Journal of Rheumatology6 (1990): 471-473.
3. Uthman I., et al. “Intra-articular therapy in osteoarthritis”. Postgraduate Medical Journal934 (2003): 449-453.
4. Hajhashemi V., et al. “Anti-inflammatory and analgesic properties of the leaf extracts and essential oil of Lavandula angustifolia Mill”. Journal of Ethnopharmacology1 (2003): 67-71.
5. Altman RD and Barthel HR. “Topical therapies for osteoarthritis”. Drugs10 (2011): 1259-1279.
6. Michalsen M., et al. “Effectiveness of leech therapy in osteoarthritis of the knee”. Annals of Internal Medicine9 (2003): 724-730.
7. Elsner G., et al. “[Knee joint arthroses and work-related factors] German [abstract]”. Soz Praventivmed2 (1996): 98-106.
8. SADDIGE Z., et al. “A review of the antibacterial activity of Hypericumperforatum L”. Journal of Ethnopharmacology3 (2010): 511-521.
9. PREETHI KC and KUTTAN R. “Wound healing activity of flower extract of Calendula officinalis”. Journal of Basic and Clinical Physiology and Pharmacology 1 (2009): 73-79.
10. MAJEWSKA I and GENDASZEWSKA-DARMACH E. “Proangiogenic activity of plant extracts in accelerating wound healing - a new face of old phytomedicines”. Acta Biochimica Polonica4 (2011): 449-360.
11. POPA C-V., et al. “Total antioxidant activity, phenols and flavonoids content of several plant extracts”. International Journal of Food Properties 3 (2012): 691-701.
12. KAUFMAN T., et al. “Topical acidification promotes healing of experimental deep partial thickness skin burns: a randomized double-blind preliminary study”. Burns2 (1985): 84-90.
13. Aya KL and Stern R. “Hyaluronan in wound healing: Rediscovering a major player”. Wound Repair and Regeneration 22 (2014): 579-593.
14. Liochev SI and Fridovich I. “Superoxide from glucose oxidase or from nitroblue tetrazolium?” Archives of Biochemistry and Biophysics 318 (1995): 408-410.
15. Shivananda Nayak B., et al. “Wound healing properties of the oils of Vitis vinifera and Vaccinium macrocarpon”. Phytotherapy Research PTR 25 (2011): 1201-1208.
16. Vakhtang B., et al. “Allantoin- and pyrrolizidine alkaloids-free wound healing compositions from Symphytum asperum”. Bulletin of the Georgian National Academy of Sciences 3 (2009): 159-164.
17. Vorauer-Uhl K., et al. “Reepithelialization of experimental scalds effected by topically applied superoxide dismutase: controlled animal studies”. Wound Repair and Regeneration 10 (2002): 366-371.
18. Wołosik K., et al. “The importance and perspective of plant-based squalene in cosmetology”. Journal of Cosmetic Sciences 64 (2013): 59-66.
19. Liu K., et al. “Isolation and biological activities of decanal, linalool, valencene, and octanal from sweet orange oil”. Journal of Food Science 77 (2012): C1156-1161.
20. Shivananda Nayak B., et al. “Wound healing properties of the oils of Vitis vinifera and Vaccinium macrocarpon”. Phytotherapy Research PTR 25 (2011): 1201-1208.

Citation

Citation: Gyanesh Kumar Sahu., et al. “A Review of Lavender Antimicrobial Ointment: Nature's Defence for Healthy Skin". Acta Scientific Pharmaceutical Sciences 9.4 (2025): 29-33.

Copyright

Copyright: © 2025 Gyanesh Kumar Sahu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.