Chavi Mittal¹*, Aayushi², Mubarik Muhamad² and Kunal Pathak²

¹Assistant Professor, School of Pharmacy and Research, Dev Bhoomi Uttrakhand University, Dehradun, India
²Scholar, School of Pharmacy and Research, Dev Bhoomi Uttrakhand University, Dehradun, India

*Corresponding Author: Chavi Mittal, Assistant Professor, School of Pharmacy and Research, Dev Bhoomi Uttrakhand University, Dehradun, India.

Received: February 08, 2025; Published: March 06, 2025

Abstract

The present study aimed to assess the pharmacological and phytochemical and pharmacogenetic properties of the Euphorbiaceae family of plants, namely Mallotus philippensis. The assessments included organoleptic, microscopical, and physicochemical analyses, and included measurements of LOD, total powder ash, percentage of extraction, swelling index, foaming index, and foreign particle., were used to conduct pharmacognostical investigations. According to the results, the LOD was determined to be 1.74 Percentage. Likely, 0.8 cm was reported as the swelling index. Index of foaming (less than 100). Through sequential soxhlet extraction, a phytochemical research was conducted. The extractive values for petroleum ether, chloroform, ethyl acetate, ethanol, and distilled water were 4.9%, 5.45%, 9.77%, 8.75%, and 4.4%, respectively. The existence of steroid, flavonoid, alkaloid, glycoside, phenolic compounds, fixed oils, and lipids was identified by the preliminary qualitative phytochemical screening. The ethyl acetate extract of the Mallotus philippensis plant was used in the pharmacological experiment to examine the anthelmetic action. The dosage of 120 mg/kg was shown to have a good pharmacological effect.

Keywords: Mallotus philippensis; Phytochemistry; Pharmacology

References

1. CJ Widen and HS Puri. “Natural occurrence and chemical variability of phloroglucinols in Kamala”. Planta Medica3 (1980): 284-287.
2. R Singh., et al. “Anti filarial activity of Mallotus philippinensis Lam. on Setaria cervie (Nematoda: Filarioidea) in-vitro”. Indian Journal of Physiology and Pharmacology4 (1997): 397-403.
3. VP Kumar., et al. “Search for antibacterial and antifungal agents from selected Indian medicinal plants”. Journal of Ethnopharmacology2 (2006): 182-188.
4. C Orwa., et al. “Agrofores tree Database: a tree reference and selection guide”. Version (2009):4.
5. K Usmanghani., et al. “Indusynic Medicine. Karachi”. Research Institute of Indusyunic Medicine (1997): 285-287.
6. VR Sharma. “A review on endangered plant of Mallotus philippinensis (Lam.) M. Arg”. Pharmacologyonline 3 (2011): 1256-1265.
7. SC Thakur., et al. “An etheral extract of Kamala (Mallotus philippinensis (Moll. Arg) Lam.) seed induce adverse effects on reproductive parameters of female rats”. Reproductive Toxicology1 (2005): 149-156.
8. ML Gujral., et al. “Oral contraceptives. II. Antifertility effect of Mallotus philippinensis”. Indian Journal of Medical Research 48 (1960): 52-58.
9. M Gangwar., et al. “Qualitative phytochemical characterization and antibacterial evaluation of glandular hairs of Mallotus philippinensis fruit extract”. Journal of Pharmacy Research11 (2011):4214-4216.
10. A Daikonya., et al. “Antiallergic agents from naturalsources 9. Inhibition of nitric oxide production by novel chalcone derivatives from Mallotus philippinensis (Euphorbiaceae)”. Chemical and Pharmaceutical Bulletin 11 (2004):1326-1329.
11. S Ramakrishna., et al. “Effect of Mallotus Philippinensis Muell.-Arg leaves against hepatotoxicity of Carbon tetrachloride in rats”. International Journal of Pharmaceutical Sciences and Research 2 (2011): 74-83.
12. KD Roberts., et al. “Glycosides and aglycons. CCLII. Cardenolides of the seed of Mallotus philippinensis”. Helvetica Chimica Acta 46 (1963): 2886-2893.
13. M Bandopadhyay., et al. “Triterpenoid and other components of Mallotus philippinensis”. Phytochemistry4 (1972): 1511.
14. SP Nair and J Madhusudana Rao. “Kamaladiol-3-acetate from the stem bark of Mallotus philippinensis”. Phytochemistry 32 (1993): 407-409.
15. T Tanaka., et al. “Dimeric chalcone derivatives from Mallotus philippinensis”. Phytochemistry8 (1998): 1423-1427.
16. M Furusawa., et al. “Novel, complex flavonoids from Mallotus philippinensis (Kamala tree)”. Helvetica Chimica Acta5 (2005): 1048-1058.
17. SFH Zaidi., et al. “Potent bactericidal constituents from Mallotus philippinensis against clarithromycin and metronidazole resistant strains of Japanese and Pakistani helicobacter pylori”. Biological and Pharmaceutical Bulletin4 (2009): 631-636.

Citation

Citation: Chavi Mittal., et al. “Mallotus philippensis: A Review on its Phytochemistry and Pharmacology". Acta Scientific Pharmaceutical Sciences 9.4 (2025): 03-14.

Copyright

Copyright: © 2025 Chavi Mittal., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.