Gitesh Sahu¹, Gitesh Sinha¹, Ujjawal Jaiswal¹, Raushani Kumari² and Gyanesh Kumar Sahu² and Gyanesh Kumar Sahu²*

¹Rungta Institute of Pharmaceutical Sciences Kohka, Bhilai, India
²Rungta Institute of Pharmaceutical Sciences and Research Kohka, Bhilai, India

*Corresponding Author: Gyanesh Kumar Sahu, Professor and Dean, Rungta Institute of Pharmaceutical Sciences and Research, Kohka, Kurud, Bhilai, India

Received: February 04, 2025; Published: February 20, 2025

Abstract

Garlic, or Allium sativum, is a known herb with several health benefits, including possible anti-diabetic effects. The purpose of this review was to explore the anti-diabetic properties of garlic, with a focus on the active ingredients, including allicin, and how they function to control blood sugar levels. Long term hyperglycemia is a main root cause of diabetes mellitus, which is associated to insulin resistance, poor glucose metabolism, and elevated oxidative stress. Garlic has showed potential in regulating these changes because of its bioactive components.
When garlic extract was assisted to diabetic animal models in animal trials, the blood glucose levels of the treated group were much lower than those of the untreated control group. The effects of the extract were attributed to its ability to improve insulin secretion, improve insulin sensitivity, and promote glucose uptake by peripheral tissues. Additionally, garlic also exhibit an inhibitory effect on essential enzyme consider for the carbohydrate digestion, such as α-amylase and α-glucosidase, which helps regulate postprandial blood glucose spikes.
Garlic also possesses potent antioxidant properties, which play a important role in reducing oxidative stress and protecting the damage of pancreatic beta cell. By neutralizing free radicals, garlic helps prevent complications associated with diabetes, such as neuropathy and nephropathy. Additionally, garlic's anti-inflammatory effects contribute to the overall improvement in metabolic health.
This review emphasizes the potential of Allium sativum as an alternative treatment for managing diabetes.

Keywords: Introduction; Diabetes mellitus; Allium sativum; Mechanism of Diabetes; Antidiabetic Property

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Citation

Citation: Gyanesh Kumar Sahu., et al. “Exploring the Role of Garlic (Allium sativum) in the Management of Diabetes Mellitus: An Overview". Acta Scientific Pharmaceutical Sciences 9.3 (2025): 36-42.

Copyright

Copyright: © 2025 Gyanesh Kumar Sahu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.