GB Alaka Kar¹, Susanta Kumar Rout²* and Debashis Mishra¹

¹IMT Pharmacy College, Puri, New Nabakalabara Road, Sai Vihar, Gopalpur, Odisha, India
²Mayurbhanj Medical Academy, Indapahi, Laxmiposi, Baripada, Odisha, India

*Corresponding Author: Susanta Kumar Rout, Mayurbhanj Medical Academy, Indapahi, Laxmiposi, Baripada, Odisha, India.

Received: January 27, 2025; Published: February 13, 2025

Abstract

Helminthiasis is a widespread parasitic infection among humans and animals caused by helminths. The disease is highly prevalent particularly in developing countries due to inadequate sanitary conditions and poor management practices. Carica papaya Linn. belonging to the family of Caricaceae is a well-known fruit and medicinal plant that has been widely used for a long time to cure various types of infectious disease especially in South Asian countries. The papaya juice mainly contains, nbutyric, n-hexanoic and n-octanoic acid, benzyl-isothiocynate, 19- carotenoids. The fruits and seed are reported to contain papain, benzythiocarbamide, pseudocarpine. Antibacterial activity of Carica papaya latex has already been studied was expressed in terms of the radius of zone inhibition. The crude latex of Carica papaya was evaluated for anthelmintic activity using adult earthworms (Pheretima posthuma and Tubifex tubifex). The dried latex exhibited a dose-dependent inhibition of spontaneous motility (paralysis) and evoked responses to pin-prick. With higher doses (80mg/ml of dry latex) the effects was comparable with the standard drug piperazine. However, there was no final recovery in the case of worms treated with latex in contrast to Albendazole with which the paralysis was reversible and the worms recovered completely within six hours. The time of paralysis and time of death were studied and the activity was compared with as reference standard and distilled water was used as control. The latex at doses 40 mg/ml and 80 mg/ml exhibited significant anthelmintic activity as evidenced by decreased paralyzing time and death time.

Keywords: Anthelmintic; Albendazole; Carica papaya; Pheretima posthuma; Tubifex tubifex

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Citation

Citation: Susanta Kumar Rout., et al. “Evaluation of Anthelmintic Activity of Carica papaya Latex in Indian Earthworm". Acta Scientific Pharmaceutical Sciences 9.3 (2025): 17-21.

Copyright

Copyright: © 2025 Susanta Kumar Rout., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.