Kenneth Kyegwim¹*, Finangwai Amos² and Kristabel Ibukun³

¹Nigerian Defense Academy, Kaduna, Nigeria
²Head of Unit SSDMQC, Jos University Teaching Hospital (JUTH), Nigeria
³Federal university Lokoja, Lokoja, Nigeria

*Corresponding Author: Kenneth Kyegwim, Nigerian Defense Academy, Kaduna, Nigeria.

Received: January 27, 2025; Published: February 12, 2025

Abstract

Introduction: Compounding is “the preparation and supply of a single unit of a product intended for immediate use by a specific patient” Pharmaceutical society of Australia (PSA). The main objective of the study was to determine the pattern of extemporaneous drug compounding in small scale drug manufacturing and quality control unit of Jos University Teaching Hospital (JUTH).

Method: This is a retrospective, cross sectional, descriptive and analytical over a period of One year from January 2014 to December 2014 on all records of drugs compounded in the small-scale drug manufacturing and quality control unit of JUTH. The result obtained was analyzed using SPSS version 20 and was presented on tables and charts as frequency and percentages.

Result: A total number of Forty (40) different drugs were compounded with a frequency of 1006 times. Averaging 84 per month. 887 (88.2%) were enterals while 119 (11.8%) were antiseptics and topicals. These drugs belongs to ten (10 ) different classes, Cardiovascular/Diuretics having Nine (9) drugs, Central Nervous System having six (6) drugs, Anti-Malarials having Three (3) drugs, Antituberculotic having Four (4) drugs, Topical having Eight (8) drugs, Antiseptics having Three (3) drugs, among the drugs compounded the highest individual drug was furosemide with a total of 194 while the highest class was Cardiovascular/Diuretics thus these shows that most of the patients treated presented with complains of edema, heart failure or hypertension. Carbamazepine was the second drug with the highest frequency of 162 belonging to a class of drugs with activity on the central nervous system was used to treat seizure disorders. The liquid preparations were done with syrup B.P and distilled water for a maximum of 14 days and packaged in 100mls amber colored bottles whereas the ointments were prepared with petroleum jelly and packaged in 75mls ointment Jars. Antiseptics were prepared in larger volumes for disinfection of the hospital.

Conclusion: 84.10% were out-patients with Furosemide the highest compounded drug used to treat congenital heart diseases. Topicals were prepared for special skin disorders as keratolytic agents. There is need for further study on stability and physico-chemical properties of the preparations for safety.

Keywords: Compounding; Jos University Teaching Hospital (JUTH)

References

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Citation

Citation: Kenneth Kyegwim., et al. “Pattern of Extemporaneous Drug Prescription and Preparation in Jos University Teaching Hospital: A One Year Retrospective Study Jan-Dec 2014". Acta Scientific Pharmaceutical Sciences 9.3 (2025): 08-16.

Copyright

Copyright: © 2025 Kenneth Kyegwim., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.