Drug Repurposing in the Era of Emerging Infectious Diseases
Reuben P Syiem1*, Namit Ray2, Krishnamoorthi R2 and Rajesh Kumar2
1Senior Resident Doctor, Department of Pharmacology, NEIGRIHMS, Shillong, India
2Post Graduate Trainee, Department of Pharmacology, NEIGRIHMS, Shillong, India
*Corresponding Author: Reuben P Syiem, Senior Resident Doctor, Department of
Pharmacology, NEIGRIHMS, Shillong, India.
Received:
January 15, 2025; Published: January 30, 2025
Abstract
Emerging infectious diseases (EIDs) pose significant challenges to global health, often resulting in substantial morbidity, mortal
ity, and economic burden. The traditional drug development process, with its prolonged timelines and high costs, cannot adequately
address the urgent need for effective therapeutics during outbreaks. Drug repurposing- leveraging approved drugs for new therapeu
tic uses, has emerged as a promising strategy to combat EIDs. This review discusses the principles, methodologies, and technologies
driving drug repurposing, along with its successful applications in recent pandemics, such as COVID-19 and Ebola. Regulatory and
ethical challenges are analyzed, emphasizing the importance of balancing speed with safety. Finally, future perspectives, including the
role of artificial intelligence and global collaboration, are explored. Drug repurposing represents a vital tool in pandemic prepared
ness, offering the potential for rapid and cost-effective responses to emerging health threats
Keywords: Drug Repurposing; Emerging Infectious Diseases; Pandemic Preparedness; High-throughput Screening; COVID-19; Arti
ficial Intelligence; Therapeutics
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