Umang Budhraja, Komal Kamble, Manish Sharma and Anamika Mishra*

Umang Global Pvt Ltd., Mumbai, Maharashtra, India

*Corresponding Author: Anamika Mishra, Umang Global Pvt Ltd., Mumbai, Maharashtra, India.

Received: January 15, 2025; Published: January 21, 2025

Abstract

Pancreatic enzyme supplements are essential in the treatment of exocrine pancreatic insufficiency (EPI), which is characterized by the pancreas's failure to release enzymes and bicarbonate necessary for effective digestion leading to impaired digestion and nu trient absorption. However, the efficacy of EC Pancreatic pellets are dependent on enzymatic activity and pH-Dependent dissolution. This study aimed to compares the enzymatic activities and in vitro dissolution at different phosphate buffer range from pH 1.2 to 7.4 of two different EC coated Pancreatic pellets i.e. Creon10k (Abbot India Pvt Ltd) and Pancrelip 10k (Umang Global Pvt Ltd). Creon 10k, a marketed formulation was compared with Pancrelip 10k which is manufactured by Umang Global Pvt Ltd. All these study methods are performed as described in the US Pharmacopeia. Studies have shown that Pancrelip 10k, when compared to Creon 10k, is a suitable substitute for treating EPI, as it shows a similar enzymatic activity for Amylase, Lipase and Protease as well as in vitro dissolution for Lipase release.

Keywords:Exocrine Pancreatic Insufficiency; EC Pancreatin Pellets; Comparison Study; Enzymatic Activity; In Vitro Dissolution; Lipase Activity

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Citation

Citation: Anamika Mishra., et al. “Creon 10k vs Pancrelip 10k: A Comparative In vitro Analysis of Lipase Activity of Pancreatin EC Pellets". Acta Scientific Pharmaceutical Sciences 9.2 (2025): 02-07.

Copyright

Copyright: © 2025 Anamika Mishra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.