Osteoarthritis and Vitamin C Pathogenic Insights and Therapeutic Potential
Ray Marks*
Department of Research, Osteoarthritis Research Center, Thornhill, Canada
*Corresponding Author: Ray Marks, Department of Research, Osteoarthritis Research Center, Thornhill, Canada.
Received:
June 10, 2024; Published: July 15, 2024
Abstract
Osteoarthritis, the most prevalent musculoskeletal disease remains relatively impervious to a desired reversal of its progressive impact on mobility and life quality. Moreover, even if available, standard treatments may not be indicated, or efficacious, or safe and commonly fail to impact the disease directly. A disease with multiple progressively degenerating physical manifestations including joint tissue damage, inflammation, and muscle pathology, antioxidants such as vitamin C may prove helpful, especially in protecting vulnerable older adults from undue pain and suffering and excess joint destruction. Building on a prior in depth overview capturing almost all data on this topic as a 2019 search, here we present some newer data on this topic published since 2019 that furthers the view that vitamin C has noteworthy anabolic and catabolic properties that can be harnessed to mediate, moderate, or even prevent osteoarthritis joint damage in later life. Its vast protective and interactive attributes with joint and brain tissues show sufficient potential in the context of osteoarthritis pain and inflammation, as well as joint structure and cartilage physiology that is of paramount importance to validate and should be intently explored to prevent overlooking a promising non narcotic osteoarthritis pain and free radical reduction source.
Keywords: Aging; Ascorbic Acid; Cartilage; Intervention; Joint Inflammation; Osteoarthritis; Pain; Vitamin C
References
- Coppola Chiara., et al. “Osteoarthritis: insights into diagnosis, pathophysiology, therapeutic avenues, and the potential of natural extracts”. Current Issues in Molecular Biology5 (2024) 4063-4105.
- Dunlap Burton., et al. “Vitamin C supplementation for the treatment of osteoarthritis: perspectives on the past, present, and future”. Therapeutic Advances in Chronic Disease12 (2021): 20406223211047026.
- Mititelu-Tartau Liliana., et al. “Editorial: vitamin C from bench to bedside”. Frontiers in Nutrition11 (2024): 1406342.
- Takisawa Shoko., et al. “Vitamin C is essential for the maintenance of skeletal muscle functions”. Biology 7 (2022).
- Crisol Mary., et al. “Antioxidant additives reduce reactive oxygen species production in articular cartilage during exposure to cryoprotective agents”. Cryobiology 96 (2020): 114-121.
- Colletti Alessandro and Arrigo F G Cicero. “Nutraceutical approach to chronic osteoarthritis: from molecular research to clinical evidence”. International Journal of Molecular Sciences23 (2021): 12920.
- Dohrn Maike F., et al. “Deoxy-sphingolipids, oxidative stress, and vitamin C correlate with qualitative and quantitative patterns of small fiber dysfunction and degeneration”. Pain9 (2022): 1800-1811.
- Han Qian-Qian., et al. “SVCT2-mediated ascorbic acid uptake buffers stress responses via DNA hydroxymethylation reprogramming of S100 calcium-binding protein A4 gene”. Redox Biology 58 (2022): 102543.
- Bharat Krish Tejas., et al. “Ingredients of a natural oral nutritional supplement and their role in the treatment of osteoarthritis”. Clinical Medicine Insights. Arthritis and Musculoskeletal Disorders15 (2022): 11795441211063365.
- Kim JR., et al. “Therapeutics in osteoarthritis based on an understanding of its molecular pathogenesis”. International Journal of Molecular Science3 (2018): pii E674.
- Ballaz SJ and Rebec GV. “Neurobiology of vitamin C: expanding the focus from antioxidant to endogenous neuromodulator”. Pharmacology Research 146 (2019): 104321.
- Grover AK and Samson SE. “Benefits of antioxidant supplements for knee osteoarthritis: rational and reality”. Nutritional Journal1 (2016).
- Choi Sooho., et al. “Advances in dermatology using DNA aptamer "Aptamin C" innovation: oxidative stress prevention and effect maximization of vitamin C through antioxidation”. Journal of Cosmetic Dermatology4 (2020): 970-976.
- Marks Ray. "Vitamin C and osteoarthritis: mini review and commentary”. CPQ Orthopaedics3 (2018): 1-16.
- Xu Chao., et al. “Role of dietary patterns and factors in determining the risk of knee osteoarthritis: a meta-analysis”. Modern Rheumatology4 (2022): 815-821.
- Frediani Jennifer K., et al. “The role of diet and non-pharmacologic supplements in the treatment of chronic neuropathic pain: a systematic review”. Pain Practice 1 (2024): 186-210.
- Ramón Ricardo., et al. “Anti-inflammatory effect of vitamin c during the postoperative period in patients subjected to total knee arthroplasty: a randomized controlled trial”. Journal of Personalized Medicine9 (2023): 1299.
- Ali Aneesh., et al. “A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis”. Biomaterials Science, 10.10 (2024): 39/d4bm00243a.
- Schwartz ER and Adamy L. “Effect of ascorbic acid on arylsulfatase activities and sulfated proteoglycan metabolism in chondrocyte cultures”. Journal of Clinical Investigation 1 (1977): 96-106.
- Mattiuzzo Elena., et al. “In vitro effects of low doses of β-caryophyllene, ascorbic acid and d-glucosamine on human chondrocyte viability and inflammation”. Pharmaceuticals 3 (2021): 286.
- Shivnath Neelam., et al. “Solanum xanthocarpum fruit extract promotes chondrocyte proliferation in vitro and protects cartilage damage in collagenase induced osteoarthritic rats (article reference number: JEP 114028)”. Journal of Ethnopharmacology274 (2021): 114028.
- Chen Zhian., et al. “Intra-articular injection of ascorbic acid enhances microfracture-mediated cartilage repair”. Scientific Reports1 (2024): 3811.
- Abpeikar Zahra., et al. “Characterization of macroporous polycaprolactone/silk fibroin/gelatin/ascorbic acid composite scaffolds and in vivoresults in a rabbit model for meniscus cartilage repair”. Cartilage2 (2021): 1583S-1601S.
- Muftic Mirsad., et al. “Evaluation of the Cartinorm use in the therapy of patients with knee osteoarthritis”. Materia Socio-Medica1 (2024): 54-58.
- Shah Shalin., et al. “Vitamin C and inflammatory cytokine levels in elective total knee arthroplasty”. Nutrition and Health2 (2020): 87-91.
- Delgado-Velandia Mario., et al. “Dietary vitamin C intake and changes in frequency, severity, and location of pain in older adults”. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences 93 (2024).
- Caterino Chiara., et al. “Clinical efficacy of Curcuvet and Boswellic acid combined with conventional nutraceutical product: an aid to canine osteoarthritis”. PloS One5 (2021): e0252279.
- Takisawa S., et al. "Vitamin C deficiency causes muscle atrophy and a deterioration in physical Performance”. Science Reports1. (2019): 4702.
- Valsamidou, Evdokia., et al. “A standardized nutraceutical supplement contributes to pain relief, improves quality of life and regulates inflammation in knee osteoarthritis patients; A randomized clinical trial”. Heliyon9 (2023): e20143.
- Oakes Bennett., et al. “Vitamin C in orthopedic practices: current concepts, novel ideas, and future perspectives”. Journal of Orthopaedic Research4 (2021): 698-706.
- Carr AC and McCall C. “The role of vitamin C in the treatment of pain: new insights”. Journal of Translational Medicine 15.1 (2017): 77.
- Dionne CE., et al. “Serum vitamin C and spinal pain: a nationwide study”. Pain11 (2016): 2527-2535.
- Luo Tianyi David., et al. “Ascorbic acid and its clinical role in orthopaedic surgery”. Journal of Surgical Orthopaedic Advances4 (2018): 261-268.
- Laumonerie P., et al. “Influence of vitamin C on the incidence of CRPS-I after subacromial shoulder surgery”. European Journal of Orthopaedic Surgery and Traumatology2 (2020): 221-226.
- Chiu P R., et al. “Vitamin C protects chondrocytes against monosodium iodoacetate-induced osteoarthritis by multiple pathways”. International Journal of Molecular Science1 (2016): pii E38.
36. Zhou Meng., et al. “ROS-induced imbalance of the miR-34a-5p/SIRT1/p53 axis triggers chronic chondrocyte injury and inflammation”. Heliyon 10.11 (2024): e31654.
- Zheng Kaiwen., et al. “Enhanced articular cartilage regeneration using costal chondrocyte-derived scaffold-free tissue engineered constructs with ascorbic acid treatment”. Journal of Orthopaedic Translation45 (2024): 140-154.
- Barker Tyler., et al. “Multi-vitamin supplementation blunts the circulating IL-6/IL-10 ratio increase after knee arthroplasty: a randomized, double-blind, placebo controlled study”. Cytokine140 (2021): 155435.
- Aïm F., et al. “Efficacy of vitamin C in preventing complex regional pain syndrome after wrist fracture: a systematic review and meta-analysis”. Orthopedic Traumatology Surgery and Research3 (2017): 465-470.
- Riffel APK ., et al. “Treatment with ascorbic acid and α-tocopherol modulates oxidative-stress markers in the spinal cord of rats with neuropathic pain”. Brazilian Journal of Medicine and Biology Research 51 (2018): e7097.
- Zară-Dănceanu Camelia Mihaela., et al. “Magnetic nanoemulsions for the intra-articular delivery of ascorbic acid and dexamethasone”. International Journal of Molecular Sciences15 (2023): 11916.
- Yamamoto Nobuyuki., et al. “Non-operative management of shoulder osteoarthritis: Current concepts”. Journal of ISAKOS : Joint Disorders and Orthopaedic Sports Medicine5 (2023): 289-295.
- Apostu Dragos., et al. “Systemic drugs with impact on osteoarthritis”. Drug Metabolism Reviews4 (2019): 498-523.
- Amr Mahmoud., et al. “In vitroeffects of nutraceutical treatment on human osteoarthritic chondrocytes of females of different age and weight groups”. Journal of Nutritional Science 10 (2021): e82.
- Zhang Xiaoyu., et al. “Vitamin C regulates skeletal muscle post-injury regeneration by promoting myoblast proliferation through its direct interaction with the Pax7 protein”. Food and Function8 (2024): 4575-4585.
- Skalny Anatoly V., et al. “Role of vitamins beyond vitamin D3in bone health and osteoporosis (Review)”. International Journal of Molecular Medicine1 (2024): 9.
- Uehara Hirohisa., et al. “The effect of vitamin C and N-Acetylcysteine on tendon-to-bone healing in a rodent model of rotator cuff repair”. The American Journal of Sports Medicine6 (2023): 1596-1607.
- Joseph Gabby B., et al. “Associations between vitamins C and D intake and cartilage composition and knee joint morphology over 4 years: data from the Osteoarthritis Initiative”. Arthritis Care and Research9 (2020): 1239-1247.
- Ranjbari Fatemeh and Ehsan Alimohammadi. “Unveiling the potential impact of vitamin C in postoperative spinal pain”. Chinese Neurosurgical Journal1 (2024) 16.
- Iliuță Daniel., et al. “Research on the influence of MUVON PLUS treatment upon the biomechanical behavior of the human osteoarthritic knee”. Current Health Sciences Journal1 (2023): 75-84.
- Leboy PS., et al. “Ascorbic acid induces alkaline phosphatase, type X collagen, and calcium deposition in cultured chick chondrocytes”. Journal of Biological Chemistry 264.29 (1989): 17281-17286.
- Röhr D., et al. “Sodium-dependent vitamin C transporter 2 deficiency impairs myelination and remyelination after injury: roles of collagen and demethylation”. Glia7 (2017): 1186-1200.
- Lindsey Richard C., et al. “Vitamin C effects on 5-hydroxymethylcytosine and gene expression in osteoblasts and chondrocytes: potential involvement of PHD2”. PloS One8 (2019): e0220653.
- Mallah Alia., et al. “Sex-specific reduction in inflammation of osteoarthritic human chondrocytes and nutraceutical-dependent extracellular matrix formation”. Journal of Immunology and Regenerative Medicine14 (2021): 100054.
- Mobasheri A., et al. “Glucose transport and metabolism in chondrocytes: a key to understanding chondrogenesis, skeletal development and cartilage degradation in osteoarthritis”. Histology and Histopathology4 (2002): 1239-1267.
Citation
Copyright