Hyacinth Tochukwu Eze¹, Ezejindu Damian Nnabuihe², Joshua Izuchukwu Abugu²* and Ifeanacho Ezeteonu Abireh³

¹Department of Internal Medicine, Nnamdi Azikiwe University, College of Medicine Nnewi Campus, Anambra State, Nigeria
²Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
³Department of Anatomy, Faculty of Basic Medical Sciences, Enugu State University of Science and Technology, Enugu State, Nigeria

*Corresponding Author: Joshua Izuchukwu Abugu, Department of Anatomy, Faculty of Basic Medical Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.

Received: May 27, 2024; Published: June 11, 2024

Abstract

This study was principally carried out to investigate the effect of Vitamins C and E on the rohypnol-induced kidney damage in male wistar rats. Twenty five adult male wistar rats were randomly divided into four groups with five rats in each group (A, B, C, D and E). Group A, the control group received distilled water. Groups B, C and D received 1 mg/kg of Rohypnol, 1 mg/kg of Rohypnol+100 mg/kg of vitamin C, 1 mg/kg of Rohypnol+100 mg/kg of vitamin E and 1 mg/kg of Rohypnol+100 mg/kg of vitamin C and E of Rohypnol respectively. The animals were anaesthesized under ketamine followed by cardiac puncture after three weeks of administration and the kidney were harvested and fixed in 10% formal saline for histological processing, blood were collected via cardiac puncture for biochemical studies. The results obtained in this study following the administration of Vitamin C&E and increasing dosage of rohypnol shows a progressive improvement in the test group when comparing to the other group. The crucial role of Vitamin C and E in renal functions, as well as responses to the histoarchitecture is well supported by the evidences presented in this study.

Keywords: Flunitrazepam Vitamin C and E (Rohypnol), Kidney; Histoarchitecture; Benzodiazepine

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Citation

Citation: Joshua Izuchukwu Abugu., et al. “Antioxidant Effects of Supplementation with Choice Vitamins C (Ascorbic Acid) And E (Tocopherol) on Rohypnol-Induced Kidney Damage of Male Wistar Rats".Acta Scientific Pharmaceutical Sciences 8.7 (2024): 36-43.

Copyright

Copyright: © 2024 Joshua Izuchukwu Abugu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.