Belide Pavani*

Department of Pharmaceutical Chemistry, CMR College of Pharmacy, Medchal, Hyderabad

*Corresponding Author: Belide Pavani, Department of Pharmaceutical Chemistry, CMR College of Pharmacy, Medchal, Hyderabad.

Received: April 15, 2024; Published: June 10, 2024

Abstract

Camellia sinensis has been used since several decades owing to its numerous health benefits. The purpose of this study is to investigate the developments in new varieties of Camellia sinensis. This new variety of tea possesses striking, purple-colored leaves, and hence, it is more commonly referred to as purple tea. This study analyzes the detailed mechanism of color change. An over-expression of genes in C. sinensis leads to an increase in the proportion of its anthocyanin content which is responsible for its color change. The genes accountable are CsAN1 (R2R3-MYB transcription factor), CsGL3 and CsEGL3 (bHLH transcription factor) and CsTTG1 (WD repeat protein). This feature stimulated us to review purple tea. The review article discusses its history, taxonomy, geography, process of cultivation and collection with the appropriate harvesting seasons, macroscopic and microscopic characteristics, and its extraction processes. The constituents obtained from Camellia sinensis and the chemical structures of its phytoconstituents were also discussed. The therapeutic properties like anti-diabetic, anti-allergic, anti-pyretic, anti-inflammatory, anti-oxidant anti-aging and anti-parasitic associated with C. sinensis are also described. C. sinensis can also be used for the treatment of osteoarthritis, obesity and cardiovascular diseases (atherosclerosis, hypertension). Furthermore, it provides protection to gastro-intestinal tract from excess secretion of gastric acid and bones from abnormal hormonal levels. It also possesses other properties for treatment of chronic diseases like Cancer and Alzheimer’s.

Keywords: Purple Tea; Anthocyanins; Catechins; Flavonoids; Antioxidants

References

1. Li XX., et al. “Anthocyanin metabolism and its differential regulation in purple tea (Camellia sinensis)”. Plant Physiology and Biochemistry (2023): 107875.
2. Jarvis C. “Purple Tea Guide: Health and Flavor - Rosie loves tea”. Rosie Loves Tea (2023).
3. Kumari M., et al. “Regulation of color transition in purple tea (Camellia sinensis)”. Planta 251 (2020): 1-18.
4. Lin C., et al. “Prophylactic effects of purple shoot green tea on cytokine immunomodulation through scavenging free radicals and no IN LPS-stimulated macrophages”. Current Issues in Molecular Biology9 (2022): 3980-4000.
5. LI MR., et al. “Research progress about the anti-aging effect and mechanism of flavonoids from traditional Chinese medicine”. Acta Pharmaceutica Sinica (2019): 1382-1391.
6. Atlas Tea Club: “What is Purple Tea? History, Benefits and More (2022).
7. Tea Research Foundation of Kenya. (2009). The tea research foundation of Kenya pre-releases purple tea variety for processing health tea product (2023).
8. World Bank Group. “Creating Kenya’s Purple Tea Market - Markets and Competition Policy in Action”. World Bank (2017).
9. Biren Shah and Avinash Seth. “Textbook of Pharmacognosy and Phytochemistry”. Elsevier India (2017).
10. Agarwal U., et al. “Review on Camellia sinensis: Nature’s gift”. International Journal of Pharmacognosy and Phytochemical Research8 (2017): 1119-1126.
11. Ahmed S and Stepp JR. “Green tea”. In Elsevier eBooks (2013): 19-31.
12. Daly D. “Growth and Culture of Camellia sinensisunder in-vitro conditions”. Research Gate (2018).
13. Choubey M., et al. “Purple Tea: Prospects of Darjeeling Tea Plantation”. International Journal of Agriculture Innovations and Research3 (2020): 169-174.
14. “Tea – Pharmacognosy”. (2019).
15. Kumari M., et al. “Regulation of color transition in purple tea (Camellia sinensis)”. Planta 251 (2020): 1-18.
16. Lu R., et al. “Independent flavonoid and anthocyanin biosynthesis in the flesh of a red-fleshed table grape revealed by metabolome and transcriptome co-analysis”. BMC Plant Biology1 (2023): 361.
17. Shui L., et al. “Characterization of the R2R3-MYB transcription factor CsMYB113 regulates anthocyanin biosynthesis in tea plants (Camellia sinensis)”. Plant Molecular Biology Reporter 1 (2023): 46-58.
18. Li Y., et al. “The research progress of main chemical constituents and functional activity in purple tea”. International Journal of Nutrition and Food Sciences1 (2021): 24.
19. Song S., et al. “An integrated metabolome and transcriptome analysis reveal the regulation mechanisms of flavonoid biosynthesis in a purple tea plant cultivar”. Frontiers in Plant Science 13 (2022): 880227.
20. Mattioli R., et al. “Anthocyanins: A comprehensive review of their chemical properties and health effects on cardiovascular and neurodegenerative diseases”. Molecules17 (2020): 3809.
21. de Sousa Moraes LF., et al. “Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes?” Critical Reviews in Food Science and Nutrition1 (2019): 59-71.
22. Abdel‐Aal EM., et al. “Identification and quantification of anthocyanin and catechin compounds in purple tea leaves and flakes”. Molecules 19 (2022): 6676.
23. Kar S., et al. “Green tea - its chemical constituents and health benefits”. International Journal of Engineering Research and Technology02 (2016).
24. Raghunath S., et al. “Processing Technologies for the Extraction of Value-Added Bioactive Compounds from Tea”. Food Engineering Reviews2 (2023): 276-308.
25. Kumar A., et al. “Major Phytochemicals: recent advances in health benefits and extraction method”. Molecules2 (2023): 887.
26. Jahanbakhsh A., et al. “Extraction of catechin as a flavonoid compound via molecularly imprinted polymers”. International Journal of Engineering5 (2022): 988-995.
27. Karima A., et al. “Effect of epigallocatechin gallate (EGCG) on neutrophils count and interleukin-6 (IL-6) expression in Pseudomonas aeruginosa keratitis: an experimental study on Rattus norvegicus rat”. Bali Medical Journal3 (2023): 2646-2655.
28. Fechtner S., et al. “Molecular insights into the differences in anti-inflammatory activities of green tea catechins on IL-1β signaling in rheumatoid arthritis synovial fibroblasts”. Toxicology and Applied Pharmacology 329 (2017): 112-120.
29. Misra S., et al. “Validation of antioxidant, antiproliferative, and in-vitroanti‐rheumatoid arthritis activities of epigallo‐catechin‐rich bioactive fraction from Camellia sinensis assamica, Assam variety white tea, and its comparative evaluation with green tea fraction”. Journal of Food Biochemistry 46.12 (2022): 14487.
30. Lee F., et al. “Hyaluronic acid-green tea catechin conjugates as a potential therapeutic agent for rheumatoid arthritis”. RSC Advances24 (2021): 14285-14294.
31. Shimoda H. “Purple tea and its extract suppress diet-induced fat accumulation in mice and human subjects by inhibiting fat absorption and enhancing hepatic carnitine palmitoyltransferase expression”. International Journal of Biomedical Science2 (2015): 67-75.
32. Suzuki T., et al. “Beneficial effects of tea and the green tea catechin epigallocatechin-3-gallate on obesity”. Molecules10 (2016): 1305.
33. Quintero-Fabián S., et al. “Role of matrix metalloproteinases in angiogenesis and cancer”. Frontiers in Oncology 9 (2019): 1370.
34. Joshi R., et al. “Anthocyanins enriched purple tea exhibits antioxidant, immunostimulatory and anticancer activities”. Journal of Food Science and Technology7 (2017): 1953-1963.
35. Stojanović S., et al. “Efficiency and mechanism of the antioxidant action of trans-resveratrol and its analogues in the radical liposome oxidation”. Archives of Biochemistry and Biophysics1 (2001): 79-89.
36. Koskei LC. “In-vitrostudies of the effects of purple tea (camellia sinensis) extracts on selected human cancer cell lines and Multi-drug Resistant Bacteria (Doctoral dissertation, University of Nairobi) (2019).
37. Rezai‐Zadeh K., et al. “Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice”. Brain Research 1214 (2008): 177-187.
38. Lin Men., et al. “Research progress of EGCG in the treatment of Alzheimer’s disease”. International Journal of Frontiers in Medicine6 (2022).
39. Hartley L., et al. “Green and black tea for the primary prevention of cardiovascular disease”. The Cochrane Library 6 (2013).
40. Antonello M., et al. “Prevention of Hypertension, Cardiovascular Damage and Endothelial Dysfunction with Green Tea Extracts”. American J of Hypertension12 (2017): 1321-1328.
41. Wen L., et al. “The Role of Catechins in Regulating Diabetes: An update review”. Nutrients21 (2022): 4681.
42. Rahimifard M., et al. “Therapeutic Effects of Gallic Acid in Regulating Senescence and Diabetes; an In-vitroStudy”. Molecules24 (2020): 5875.
43. Wu X., et al. “EGCG-derived polymeric oxidation products enhance insulin sensitivity in db/db mice”. Redox Biology 51 (2022): 102259.
44. Andrade JP. “Protective action of green tea catechins in neuronal mitochondria during aging”. Frontiers in Bioscience2 (2015): 247-262.
45. Haque A., et al. “Long-Term administration of green tea catechins improves spatial cognition learning ability in rats”. Journal of Nutrition4 (2006): 1043-1047.
46. Wang L., et al. “Protective effect of green tea catechin against urban fine dust particle-induced skin aging by regulation of NF-κB, AP-1, and MAPKs signaling pathways”. Environmental Pollution 252 (2019): 1318-1324.
47. Unno K., et al. “Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)”. Experimental Gerontology7 (2004): 1027-1034.
48. Fei T., et al. “The anti-aging and anti-oxidation effects of tea water extract in Caenorhabditis elegans”. Experimental Gerontology 97 (2017): 89-96.
49. Geoffrey KK., et al. “Qualitative Phytochemical Screening of Camellia sinensisand Psidium guajava Leave Extracts from Kericho and Baringo Counties”. International Journal of Advanced Biotechnology and Research (IJBR) 3 (2020): 506-512.
50. Rashid K., et al. “Kenyan purple tea anthocyanins and coenzyme-Q10 ameliorate post treatment reactive encephalopathy associated with cerebral human African trypanosomiasis in murine model”. Parasitology International2 (2014): 417-426.
51. Li Q., et al. “The anti-allergic potential of tea: a review of its components, mechanisms and risks”. Food and Function1 (2021): 57-69.
52. Balaji G., et al. “Mast cell stabilizing and anti-anaphylactic activity of aqueous extract of green tea (Camellia sinensis)”. International Journal of Veterinary Science and Medicine1 (2014): 89-94.
53. Ray S., et al. “GC-MS based metabolite profiling and angiotensin I-converting enzyme inhibitory property of black tea extracts”. Revista brasileira De Farmacognosia5 (2017): 580-586.
54. Moore RJ., et al. “Green tea (Camellia sinensis) catechins and vascular function”. British Journal of Nutrition 12 (2009): 1790-1802.
55. Ratnasooriya W and Fernando TSP. “Gastroprotective activity of Camellia sinensisblack tea brew in rats”. Pharmaceutical Biology8 (2009): 675-682.
56. Ngobidi KC., et al. “Anti-Ulcerative effect of ethanol leaf extract of camellia sinensis on albino rats induced ulcer with ethanol”. International Journal of Pharma and Bio Sciences 7 (2016): 28-33.
57. Hajihossein R., et al. “Anti-Acanthamoeba effect of Camellia sinensisextract (black and green tea) in-vitro”. Journal of Medicinal Plants 19 (2020): 163-169.
58. Sosa AM., et al. “Efficacy of topical treatment with (−)-epigallocatechin gallate, a green tea catechin, in mice with cutaneous leishmaniasis”. Molecules 7 (2020): 1741.
59. Das AS., et al. “Evidence for a prospective anti-osteoporosis effect of black tea (Camellia Sinensis) extract in a bilaterally ovariectomized rat model”. Asia Pacific Journal of Clinical Nutrition 2 (2004): 210-216.
60. Mitra C., et al. “Black Tea (Camellia sinensis) and Bone Loss Protection”. Tea in Health and Disease Prevention (2013): 603-612.

Citation

Citation: Belide Pavani. “Purple Tea: A Systematic Review".Acta Scientific Pharmaceutical Sciences 8.7 (2024): 19-29.

Copyright

Copyright: © 2024 Belide Pavani. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.