Elsa Ansari¹*, Emmanson Emmanson², Sunday Kaura³, Ebele Lauretta Iloanya⁴, Anthonia B Ojomo⁵ and Ololade Comfort Olawoyin⁶

¹Department: Chemistry, University of Sindh Jamshoro, Pakistan
²Sacred Heart College of Nursing Sciences, Pakistan
³Verittas University, Nigeria
⁴Department: Applied Biochemistry, Nnamdi Azikiwe University, Nigeria
⁵Department of Pharmacy, Universite De Parakou, Benin
⁶Biological Science Department, Federal Poly Bida, Nigeria

*Corresponding Author: Elsa Ansari, Department of Chemistry, University of Sindh Jamshoro, Pakistan.

Received: May 24, 2024; Published: May 31, 2024

Abstract

This study investigates the long-term effects and cellular mechanisms of resveratrol, fisetin, and senolytics on human healthspan and lifespan using animal model studies. The experimental cohort comprised male C57BL/6 mice randomly assigned to treatment groups: resveratrol, fisetin, senolytics, or control. Lifespan was evaluated using Kaplan-Meier survival analysis, revealing significant extensions in mice treated with resveratrol (p < 0.05) and fisetin (p < 0.05) compared to controls, suggesting their potential to enhance longevity. Furthermore, resveratrol and fisetin treatment demonstrated improvements in healthspan indicators, including physical activity levels, cognitive function, metabolic parameters, and age-related pathologies.
Resveratrol-treated mice exhibited increased physical activity levels compared to controls, while fisetin-treated mice showed enhanced cognitive function in spatial memory tasks. Additionally, both resveratrol and fisetin treatment led to improvements in metabolic parameters, such as glucose tolerance and insulin sensitivity, and reductions in age-related pathologies, including inflammation and oxidative damage.
Mechanistic analyses revealed distinct cellular pathways underlying the effects of resveratrol, fisetin, and senolytics. Resveratrol activated sirtuins and AMPK signaling pathways, while fisetin exhibited antioxidant, anti-inflammatory, and neuroprotective properties. Senolytics treatment showed trends in reducing senescent cell burden and attenuating age-related decline in tissue function.
Despite promising findings, limitations include the use of animal models, which may not fully replicate human aging, and the need for further validation in human populations. Additionally, the specific dosages and treatment regimens used may not directly translate to human applications.
Resveratrol, fisetin, and senolytics show promise as interventions for promoting healthy aging and extending lifespan. Further research, including clinical trials in human populations, mechanistic studies, and exploration of combination therapies, is warranted to validate these findings and translate them into clinical practice. Collaborative efforts are crucial to harness the potential of these compounds and improve health outcomes in aging populations.

Keywords: Long-Term Effects; Cellular Mechanisms; Resveratrol; Fisetin; Senolytics; Human Healthspan; Lifespan; Animal Model Studies

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Citation

Citation: Elsa Ansari., et al. “A Research on Long-Term Effects and Cellular Mechanisms of Resveratrol, Fisetin, and Senolytics on Human Healthspan and Lifespan: Insights from Animal Model Studies".Acta Scientific Pharmaceutical Sciences 8.6 (2024): 115-124.

Copyright

Copyright: © 2024 Elsa Ansari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.