Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 8 Issue 6

Advances in Topical Drug Delivery System for the Impressive Management of Fungal Bugs

Abhay Pratap, Anupriya Kapoor, Ajay Kumar, Manisha Trivedi and Shashi Kiran Misra*

School of Pharmaceutical Sciences, CSJM University, Kanpur, India

*Corresponding Author: Shashi Kiran Misra, Director, School of Pharmaceutical Sciences, CSJM University, Kanpur, India.

Received: April 30, 2024; Published: May 06, 2024

Abstract

Drug delivery systems show how a medicinal substance is delivered to the intended location to provide a therapeutic effect. These days, fungi are responsible for an increasing number of ailments all over the world. Four types of infections may be distinguished: cutaneous mycosis, subcutaneous mycosis, superficial mycosis, and systemic mycosis. It is believed by researchers that treating these mycoses with only currently known antifungal agents would not be enough. A novel antifungal medication that acts on the target locations must go through a protracted research process, several animal and human clinical tests and trials, development, and regulatory approval before it can be introduced to the market. It is time-consuming, expensive, and likely to fail. As a result, changes to the current medication delivery system have always been considered and are being sought in novel ways. Novel developments in antifungal drug delivery systems have been created and managed to overcome the problems of dissolution, stability, bioavailability, safety, and efficacy existing in conventional formulations and procedures by applying the understanding of pharmacodynamics and pharmacokinetic principles. The four main categories of advancements in the delivery of antifungal medications include vesicular systems, Nano particulate-based structures, colloidal carriers, and various drug delivery systems. Amphotericin B and other azole types are examples of well-established therapeutic drugs for antifungal therapy that may be designed into many different carriers and delivery systems that are tailored to the patient's sickness level and the affected area. New avenues for reducing therapeutic side effects have been made possible by innovative antifungal drug delivery methods.

Keywords: Topical Delivery; Antifungal Drugs; Nanotechnology; Colloidal Carriers

References

  1. Kaur Indu Pal and Shilpa Kakkar. "Topical delivery of antifungal agents”. Expert Opinion on Drug Delivery11 (2010): 1303-1327.
  2. Mehra Tarun., et al. "Alternative approaches to antifungal therapies”. Experimental Dermatology10 (2012): 778-782.
  3. El Mahrab Robert., et al. "New developments in topical antifungal therapy”. American Journal of Drug Delivery4 (2006): 231-247.
  4. Ma Z., et al. "Advances in anti-invasive fungal drug delivery systems”. Journal of Zhejiang University (Medical Sciences)3 (2023): 318-327.
  5. Nene Shweta., et al. "Lipid based nanocarriers: A novel paradigm for topical antifungal therapy”. Journal of Drug Delivery Science and Technology62 (2021): 102397.
  6. Mansuri Shakir., et al. "Mucoadhesion: A promising approach in drug delivery system”. Reactive and Functional Polymers100 (2016): 151-172.
  7. Trombino Sonia., et al. "Solid lipid nanoparticles for antifungal drugs delivery for topical applications”. Therapeutic Delivery9 (2016): 639-647.
  8. Souza Ana CO and Andre C Amaral. "Antifungal therapy for systemic mycosis and the nanobiotechnology era: improving efficacy, biodistribution and toxicity”. Frontiers in Microbiology8 (2017): 244287.
  9. Osanloo, Mahmoud., et al. "Niosome-loaded antifungal drugs as an effective nanocarrier system: A mini review”. Current Medical Mycology4 (2018): 31.
  10. Khalil Rawia M., et al. "Formulation and characterization of nystatin-loaded nanostructured lipid carriers for topical delivery against cutaneous candidiasis”. British Journal of Pharmaceutical and Medical Research 4 (2014): 490-512.
  11. Walsh T J., et al. "New targets and delivery systems for antifungal therapy”. Sabouraudia1 (2000): 335-347.
  12. Waghule Tejashree., et al. "Emerging role of nanocarriers based topical delivery of anti‐fungal agents in combating growing fungal infections”. Dermatologic Therapy6 (2020): e13905.
  13. Nagasa Gamachu Diba and Anteneh Belete. "Review on nanomaterials and nano-scaled systems for topical and systemic delivery of antifungal drugs”. Journal of Multidisciplinary Healthcare (2022): 1819-1840.
  14. Ahmed Sadek., et al. "A comprehensive review on recent nanosystems for enhancing antifungal activity of fenticonazole nitrate from different routes of administration”. Drug Delivery1 (2023): 2179129.
  15. Spadari Cristina de Castro., et al. "Potential use of alginate-based carriers as antifungal delivery system”. Frontiers in Microbiology8 (2017): 241872.
  16. Misra S K., et al. “Tolnaftate–graphene composite-loaded nanoengineered electrospun scaffolds as efficient therapeutic dressing material for regimen of dermatomycosis”. Applied Nanoscience8 (2018): 1629-1640.
  17. Rai M., et al. "Nanotechnology for the treatment of fungal infections on human skin”. The microbiology of skin, soft tissue, bone and joint infections. Academic Press, (2017): 169-184.
  18. Nagpal Manju and Malkiet Kaur. "Nanomaterials for skin antifungal therapy: An updated review”. Journal of Applied Pharmaceutical Science1 (2021): 015-025.
  19. Mucoadhesive Drug Delivery System: A Review (2018).
  20. Shaikh Rahamatullah., et al. "Mucoadhesive drug delivery systems”. Journal of Pharmacy and Bioallied Sciences1 (2011): 89-100.
  21. Dhanjal DS., et al. “Mycology-nanotechnology interface: applications in medicine and cosmetology”. International Journal of Nanomedicine (2022): 2505-2533.
  22. Prow Tarl W., et al. "Nanoparticles and microparticles for skin drug delivery”. Advanced Drug Delivery Reviews6 (2011): 470-491.
  23. Osanloo Mahmoud., et al. "Niosome-loaded antifungal drugs as an effective nanocarrier system: A mini review”. Current Medical Mycology4 (2018): 31.
  24. Misra SK., et al. “Tolnaftate-Loaded Polyacrylate Electrospun Nanofibers for an Impressive Regimen on Dermatophytosis”. Fibers (2017): 41.
  25. Nene Shweta., et al. "Lipid based nanocarriers: A novel paradigm for topical antifungal therapy”. Journal of Drug Delivery Science and Technology62 (2021): 102397.
  26. Roberts M S., et al. "Topical and cutaneous delivery using nanosystems”. Journal of Controlled Release247 (2017): 86-105.
  27. Wang Fang., et al. "Cross-linked fluorescent supramolecular nanoparticles for intradermal controlled release of antifungal drug—A therapeutic approach for onychomycosis”. ACS Nano7 (2018): 6851-6859.
  28. Araujo Victor Hugo Sousa., et al. "Nanosystems against candidiasis: a review of studies performed over the last two decades”. Critical Reviews in Microbiology5 (2020): 508-547.
  29. Pianalto Kaila M and J Andrew Alspaugh. "New horizons in antifungal therapy”. Journal of Fungi4 (2016): 26.
  30. Kapoor Anupriya and Navneet Verma. "Acitretin Loaded Nanocarrier Gel: Formulation and Exploration of In-vitro Release Kinetics”. Current Nanomedicine (Formerly: Recent Patents on Nanomedicine)2 (2021): 102-111.
  31. Pandey Prashant., et al. "Tolnaftate Microsponges Embedded Biocompatible Gels For Controlled And Effective Antidermatophytic Activity”. International Research Journal of Pharmacy6 (2018).
  32. Gupta Prakash Chandra., et al. “Designing and characterization of econazole nitrate nanostructured lipid carriers gel for topical delivery”. European Journal of Pharmaceutical and Medical Research6 (2018): 559-567.

Citation

Citation: Shashi Kiran Misra., et al. “Advances in Topical Drug Delivery System for the Impressive Management of Fungal Bugs".Acta Scientific Pharmaceutical Sciences 8.6 (2024): 19-27.

Copyright

Copyright: © 2024 Shashi Kiran Misra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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