Priyanka Das, Vibha Aggrawal, Avinaash Chaurasiya and Akhileshwar Kumar Srivastava*

Department of Biotechnology, Sri Agrasen Kanya P.G. College, Bulanala, Varanasi, India

*Corresponding Author:Akhileshwar Kumar Srivastava, Department of Biotechnology, Sri Agrasen Kanya P.G. College, Bulanala, Varanasi, India.

Received: February 05, 2024; Published: February 21, 2024

Abstract

NF-κB plays important role in inflammatory response. Hence, the method of inhibiting NF-κB signaling has potential therapeutic application in cancer and inflammatory diseases. Conventional drug vinpocetine is used for treatment of cancer. The other conventional drug (vindoline, vindolinine, catharoseumine) are used for diabetes, curing hypoglycemic effects, curing hypertension and cancer too. The present study is explore vindoline, vindolinine and catharoseumine in comparison to vinpocetine by using molecular docking. The online server ‘swiss ADME analysis’ detected the physiochemical pharmacokinetics and drug likeness score and medicinal chemistry of vinpocetine and conventional drugs. Results from swiss ADME analysis showed that vinpocetine and conventional drugs did not violate the “Lipinski five rule” for drug. The resulted binding energy of vindoline, vindolinine and catharoseumine were -6.5, -8.17 and -8.6 respectively. The binding energy (-8.6 kcal/mol) of catharoseumine was higher than vinpocetine (-7.35 kcal/mol). Thus, catharoseumine has greater potential to interact with interacting residues of NF-κB further consideration as an anti cancerous regimen.

Keywords: Tumor; NF-κB Protein; Phytochemical; Catharanthus Roseus; Medicinal Plant

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Citation

Citation: Akhileshwar Kumar Srivastava. “Structure Based Analysis of Tumor Inducing NF-κB Protein Using Phytochemical from Catharanthus Roseus Medicinal Plant".Acta Scientific Pharmaceutical Sciences 8.3 (2024): 44-56.

Copyright

Copyright: © 2024 Akhileshwar Kumar Srivastava. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.