Aishwarya Jain* and Kiran Bhise

Department of Pharmaceutics, Allana College of Pharmacy, K.B. Hidayatullah Road, Azam Campus, Pune, Maharashtra, India

*Corresponding Author: Aishwarya Jain, Department of Pharmaceutics, Allana College of Pharmacy, K.B. Hidayatullah Road, Azam Campus, Pune, Maharashtra, India.

Received: December 15, 2023; Published: January 17, 2024

Abstract

The field of nanotechnology has shown great interest in nanoparticle synthesis, but traditional methods have raised concerns regarding health and environmental implications. In response, green nanoparticle synthesis has emerged as a promising alternative, utilizing biological agents such as plant extracts, bacteria, fungi, and algae as reducing and stabilizing agents. This review article explores recent advancements in green synthesis, focusing on the synthesis, characterization, and applications of nanoparticles. The process involves selecting a biological agent, preparing an extract, reducing metal ions, and characterising the resulting nanoparticles. Green-synthesized nanoparticles have demonstrated potential in agriculture, energy, and medicine, although their unique properties may pose challenges in these fields. Notably, they have shown promise in treating cancer, bacterial infections, and other diseases, as well as contributing to energy applications and agriculture. The use of organic agents in nanoparticle synthesis presents a smart, eco-friendly, and promising approach for diverse applications.

Keywords: Green Synthesis; Nanoparticles; Biological Agents; Plant Extracts; Biocompatibility

References

1. Ahmad N., et al. “Biogenic synthesis of nanoparticles: An eco-friendly approach”. Journal of Nanoparticle Research4 (2016): 101.
2. Iravani S. “Green synthesis of metal nanoparticles using plants”. Green Chemistry10 (2011): 2638-2650.
3. Rai M., et al. “Silver nanoparticles as a new generation of antimicrobials”. Biotechnology Advances1 (2009): 76-83.
4. Singh P., et al. “Green synthesis of nanoparticles: Their advantages and disadvantages”. AIP Conference Proceedings1 (2016): 020048.
5. Vankar PS and Bajpai D. “Prospects of using plant extracts for synthesis of silver nanoparticles”. International Journal of Chemical Studies2 (2017): 177-180.
6. Zhang XF., et al. “Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches”. International Journal of Molecular Sciences9 (2016): 1534.
7. Vankar PS and Bajpai D. “Prospects of using plant extracts for synthesis of silver nanoparticles”. International Journal of Chemical Studies2 (2017): 177-180.
8. Zhang XF., et al. “Silver nanoparticles: synthesis, characterization, properties, applications, and therapeutic approaches”. International Journal of Molecular Sciences9 (2016): 1534.
9. "Fungal Nanobionics: Principles and Applications", Springer Science and Business Media LLC (2018).
10. "Nanoparticles and their Biomedical Applications", Springer Science and Business Media LLC (2020).
11. Ana-Maria Pesterau., et al. “Method for Obtaining and Physico Chemical Characterization of Collagenic Extract of Rhizostoma Pulmo from the Black Sea". European Journal of Natural Sciences and Medicine (2022).
12. Sefali R Patel., et al. “Pristine, Ni- and Zn-Doped CuSe Nanoparticles: An Antimicrobial, Antioxidant, and Cytotoxicity Study". ACS Applied Bio Materials (2023).
13. Singh R., et al. “Green Biosynthesis of Silver Nanoparticles Using Leaf Extract of Carissa carandas L. and Their Antioxidant and Antimicrobial Activity against Human Pathogenic Bacteria”. Biomolecules 11 (2021): 299.
14. Zaeem A., et al. “Effects of Biogenic Zinc Oxide Nanoparticles on Growth and Oxidative Stress Response in Flax Seedlings vs. In Vitro Cultures: A Comparative Analysis”. Biomolecules 10 (2020): 918.
15. Srihasam S., et al. “Phytogenic Generation of NiO Nanoparticles Using Stevia Leaf Extract and Evaluation of Their In-Vitro Antioxidant and Antimicrobial Properties”. Biomolecules 10 (2020): 89.
16. Wahid I., et al. “Silver Nanoparticle Regulates Salt Tolerance in Wheat Through Changes in ABA Concentration, Ion Homeostasis, and Defense Systems”. Biomolecules 10 (2020): 1506.
17. Hossain A., et al. “Lemon-Fruit-Based Green Synthesis of Zinc Oxide Nanoparticles and Titanium Dioxide Nanoparticles against Soft Rot Bacterial Pathogen Dickeya dadantii”. Biomolecules 9 (2019): 863.
18. Ahmad H., et al. “Green Synthesis and Characterization of Zinc Oxide Nanoparticles Using Eucalyptus globules and Their Fungicidal Ability Against Pathogenic Fungi of Apple Orchards”. Biomolecules 10 (2020): 425.
19. Cherian T., et al. “Cymbopogon Citratus Functionalized Green Synthesis of CuO-Nanoparticles: Novel Prospects as Antibacterial and Antibiofilm Agents. Biomolecules 10 (2020): 169.
20. Prasad KS., et al. “Tumoricidal and Bactericidal Properties of ZnONPs Synthesized Using Cassia auriculata Leaf Extract”. Biomolecules 10 (2020): 982.
21. Silva Viana RL., et al. “Green Synthesis of Antileishmanial and Antifungal Silver Nanoparticles Using Corn Cob Xylan as a Reducing and Stabilizing Agent”. Biomolecules 10 (2020): 1235.
22. Ansari MA., et al. “Cinnamomum verum Bark Extract Mediated Green Synthesis of ZnO Nanoparticles and Their Antibacterial Potentiality”. Biomolecules 10 (2020): 336.
23. Perveen K., et al. “Microwave- Assisted Rapid Green Synthesis of Gold Nanoparticles Using Seed Extract of Trachyspermum ammi: ROS Mediated Biofilm Inhibition and Anticancer Activity”. Biomolecules 11 (2021): 197.
24. Mickymaray S. “One-step Synthesis of Silver Nanoparticles Using Saudi Arabian Desert Seasonal Plant Sisymbrium irio and Antibacterial Activity Against Multidrug-Resistant Bacterial Strains”. Biomolecules 9 (2019): 662.
25. Tolaymat TM., et al. “An evidence-based environmental perspective of manufactured silver nanoparticle in syntheses and applications: A systematic review and critical appraisal of peer-reviewed scientific papers”. Science of The Total Environment 408 (2010): 999-1006.
26. Ghosh P., et al. “Gold nanoparticles in delivery applications”. Advanced Drug Delivery Reviews 60 (2008): 1307-1315.
27. Jain PK., et al. “Calculated absorption and scattering properties of gold nanoparticles of different size, shape, and composition: Applications in biological imaging and biomedicine”. The Journal of Physical Chemistry B 110 (2006): 7238-7248.
28. Jeong S., et al. “Low-toxicity chitosan gold nanoparticles for small hairpin RNA delivery in human lung adenocarcinoma cells”. Journal of Materials Chemistry 21 (2011): 13853-13859.
29. Lu J., et al. "Biogenic silver nanoparticles by Cacumen Platycladi extract: synthesis, characterization, and antibacterial activity”. Industrial Crops and Products 62 (2014): 1-7.
30. Mittal A K., et al. "Biosynthesis of silver nanoparticles: Elucidation of prospective mechanism and therapeutic potential”. Journal of Colloid and Interface Science 415 (2014): 39-47.
31. Rajakumar G and Rahuman A A. "Evaluation of leaf aqueous extract and synthesized silver nanoparticles using Nerium oleander against Anopheles stephensi (Diptera: Culicidae)”. Parasitology Research6 (2012): 2349-2361.
32. Iravani S., et al. "Green synthesis of gold nanoparticles using Sumac aqueous extract and their antioxidant activity”. Materials Research Bulletin 99 (2018): 80-86.
33. Xia Y., et al. "Shape-Controlled Synthesis of Metal Nanocrystals: Simple Chemistry Meets Complex Physics?" Angewandte Chemie International Edition1 (2009): 60-103.
34. Parveen K., et al. "Biogenic synthesis of nanoparticles and potential applications: an eco-friendly approach”. Journal of Nanoscience and Nanotechnology10 (2018): 6261-6276.
35. Vijayaraghavan K., et al. “One-step green synthesis of ZnO nanoparticles using Aegle marmelos leaf extract: Characterization, antimicrobial and anticancer activities”. Materials Science and Engineering: C 91 (2018): 363-371.
36. Kumar A., et al. “Phytosynthesis and characterization of Fe0 nanoparticles using Aloe vera plant extract for groundwater remediation”. Journal of Cleaner Production 183 (2018): 83-92.
37. Singh P., et al. “Biological synthesis of nanoparticles from plants and microorganisms”. Trends in Biotechnology5 (2015): 294-306.
38. Husseiny M I., et al. “Biosynthesis of gold nanoparticles using Pseudomonas aeruginosa”. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy3-4 (2007): 1003-1006.
39. Tippayawat P., et al. “Green synthesis of silver nanoparticles in aloe vera plant extract prepared by a hydrothermal method and their synergistic antibacterial activity”. Peer Journal 4 (2016): e2589.
40. Smitha SL., et al. “Green synthesis of gold nanoparticles using Cinnamomum zeylanicum leaf broth”. Spectrochim Acta A Mol Biomol Spectrosc3 (2009): 735-739.
41. Ghorbani H R., et al. “Green synthesis of silver nanoparticles using Fusarium oxysporum and antibacterial activity evaluation”. Journal of Genetic Engineering and Biotechnology1 (2018): 161-166.
42. Mittal A K., et al. "Biosynthesis of silver nanoparticles: Elucidation of prospective mechanism and therapeutic potential”. Journal of Colloid and Interface Science 415 (2014): 39-47.
43. Lingaraju Kaushik., et al. “Biogenic synthesis of zinc oxide nanoparticles using Ruta graveolens (L.) and their antibacterial and antioxidant activities”. Applied Nanoscience 6 (2015).
44. Javid-Naderi., et al. “Green synthesis of copper oxide nanoparticles using okra (Abelmoschus esculentus) fruit extract and assessment of their cytotoxicity and photocatalytic applications”. Environmental Technology and Innovation 32 (2023): 103300.
45. Chandran S P., et al. “Synthesis of gold nanotriangles and silver nanoparticles using Aloe vera plant extract”. Biotechnology Progress2 (2006): 577-583.
46. Mohammadian A., et al. “A novel approach to green synthesis of silver nanoparticles using Saccharomyces cerevisiae”. Biochemical Engineering Journal 160 (2020): 107665.
47. Shah M., et al. “Green synthesis of metallic nanoparticles via biological entities”. Materials11 (2015): 7278-7308.

Citation

Citation: Aishwarya Jain and Kiran Bhise. “An Innovative Approach to Material Science: Biogenic Synthesis of Nanoparticles".Acta Scientific Pharmaceutical Sciences 8.2 (2024): 35-42.

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Copyright: © 2024 Aishwarya Jain and Kiran Bhise. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.