Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 8 Issue 1

Metoprolol Exhibits Discrete Pharmacokinetics Using Various Sites of Sample Collections after Single Oral Dose Administration of Metoprolol Tartrate in SD Rats

Yeshwant Singh*, Giridhar Bilagi, Theertha Thykandy, Krishnaraj Parit, Tejaswini Sakkuru, Sudhir K Tiwari and Pratima Srivastava

Drug Metabolism and Pharmacokinetics Division, Aragen Life Sciences, (Previously GVK Biosciences), Bengaluru, India

*Corresponding Author: Yeshwant Singh, Drug Metabolism and Pharmacokinetics Division, Aragen Life Sciences, (Previously GVK Biosciences), Bengaluru, India.

Received: November 21, 2023; Published: December 17, 2023

Abstract

The aim of the study was to investigate the influences of various routes of sampling on the pharmacokinetics profile metoprolol after single oral dose administration of metoprolol tartrate in rats. For this single dose parallel studies were conducted in SD rats at 5 mg/kg of metoprolol tartrate. In our investigation, significant differences were observed in the plasma PK profile of metoprolol using various routes of sample collection. The mean peak plasma metoprolol concentration obtained from jugular (Cmax; 170.0 ng/ mL) and saphenous (Cmax; 113.2 ng/mL) routes were comparable. Similarly, retro-orbital route Cmax (50.0 ng/mL) was comparable with Cmax (76.2 ng/mL) of femoral route. In contrast, the Cmax (39.3 ng/mL) obtained from tail vein sampling route was significantly different (p ≤ 0.05) from all other sampling sites. The Cmax obtained from tail vein sampling site was approximately 2-4 folds less compared to other routes of sampling except for retro-orbital sampling site. Corresponding differences were also observed for other PK parameters. It was concluded that the sampling sites have profound impact on the PK parameters of metoprolol after single dose oral administration in rats.

Keywords: Bioavailability; Femoral; Jugular; Metoprolol; Pharmacokinetics; Sampling site

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Citation

Citation: Yeshwant Singh., et al. “Metoprolol Exhibits Discrete Pharmacokinetics Using Various Sites of Sample Collections after Single Oral Dose Administration of Metoprolol Tartrate in SD Rats".Acta Scientific Pharmaceutical Sciences 8.1 (2024): 68-72.

Copyright

Copyright: © 2024 Yeshwant Singh., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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