Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 7 Issue 12

Zinc(II) Complexes with One Isomer of Tetraazamacrocyclic Ligand and its N-Pendent Bis-cyanoethyl Derivative: Synthesis, Characterization and Antibacterial Studies

Snehashis Roy1, Saswata Rabi2, Avijit Chakrabarty1, Pradip Paul1, Debashis Palit1 and Tapashi Ghosh Roy1*

1Department of Chemistry, University of Chittagong, Chattogram, Bangladesh
2Department of Chemistry, Chittagong University of Engineering and Technology, Chattogram, Bangladesh

*Corresponding Author: Tapashi Ghosh Roy, Department of Chemistry, University of Chittagong, Chattogram, Bangladesh.

Received: October 04, 2023; Published: November 03, 2023


Isomeric ligand, tet-b was produced by the reduction of hexamethyl tetraazacyclotetradecadiene diperchlorate salt, Me6[14]diene.2HClO4 and N–pendent bis-cyanoethyl derivative tet-bx, of this isomeric ligand was obtained by refluxing tet-b with excess of acrylonitrile. Reactions of tet-b and tet-bx with zinc(II) perchlorate and zinc(II) chloride yielded octahedral diperchloratozinc(II) complex, [Zn(tet-b)(ClO4)2] and square pyramidal monochloridozinc(II) chloride complex, [Zn(tet-bx)Cl]Cl respectively. The complex, [Zn(tet-b)(ClO4)] underwent partial axial substitution reactions with KNO3 and NaNO2 to yield square pyramidal complexes, mononitratozinc(II) perchlorate, [Zn(tet-b)(NO3)](ClO4) and mononitrozinc(II) perchlorate, [Zn(tet-b)(NO2)](ClO4) respectively. Moreover, the [Zn(tet-bx)Cl]Cl produced square pyramidal monoisothiocyanatozinc(II) thiocyanate [Zn(tet-bx)(NCS)](NCS) and octahedral diisothiocyanatozinc(II) [Zn(tet-bx)(NCS)2] complex by undergoing simultaneous axial substitution and anion exchange and axial addition and substitution with KSCN respectively. However, the same complex underwent axial substitution and anion exchange reactions with KNO3, NaNO2, KI and KBr to yield square pyramidal complexes, [Zn(tet-bx)(NO3)](NO3), [Zn(tet-bx)(NO2)](NO2), [Zn(tet-bx)I]I and [Zn(tet-bx)Br]Br respectively. The complexes have been characterized on the basis of analytical and spectroscopic data. The antibacterial activities of the ligands and theirmm new zinc(II) complexes have been investigated against some selected bacteria.

Keywords: N-pendent derivative; Zinc(II) complexes; Characterization; Addition and substitution reactions; Antibacterial


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Citation: Tapashi Ghosh Roy., et al. “Zinc(II) Complexes with One Isomer of Tetraazamacrocyclic Ligand and its N-Pendent Bis-cyanoethyl Derivative: Synthesis, Characterization and Antibacterial Studies".Acta Scientific Pharmaceutical Sciences 7.12 (2023): 13-20.


Copyright: © 2023 Tapashi Ghosh Roy., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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