Lakshman Kumar Earle and Mukthinuthalapati Mathrusri Annapurna*

Department of Pharmaceutical Analysis, GITAM School of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, AP, India

*Corresponding Author:Mukthinuthalapati Mathrusri Annapurna, Department of Pharmaceutical Analysis, GITAM School of Pharmacy, GITAM (Deemed to be) University, Visakhapatnam, AP, India.

Received: October 25, 2023; Published: October 31, 2023

Abstract

Imatinib mesylate is an anti-cancer agent used for the treatment of Myeloid leukemia. Three chemometric assisted UV-spectrophotometric methods have been developed for the estimation of Imatinib mesylate tablet formulations. A double beam UV-VIS spectrophotometer (Shimadzu Model No. UV-1800) was used for the study. Imatinib mesylate has shown linearity over the concentration range 1-30, 0.1-30 and 0.5-30 μg/mL in phosphate buffer (pH 8.0), borate buffer (pH 9.0) and in 0.1N hydrochloric acid solution in zero order as well as first order derivative spectrophotometric techniques. The proposed methods were validated as per ICH guidelines.

Keywords: Imatinib Mesylate; Derivative Spectroscopy; ICH Guidelines; Validation

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Citation

Citation: Lakshman Kumar Earle and Mukthinuthalapati Mathrusri Annapurna. “Chemo-metric Assisted UV - Spectrophotometric Methods for the Estimation of Imatinib Mesylate-An Anti Cancer Drug".Acta Scientific Pharmaceutical Sciences 7.11 (2023): 53-58.

Copyright

Copyright: © 2023 Lakshman Kumar Earle and Mukthinuthalapati Mathrusri Annapurna. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.