Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 7 Issue 11

Synthesis, Characterization and Anti-bacterial Activity of Co(II) and Ni(II) Complexes with a NSO Donating Site Schiff Base Ligand Derived from N-ethylhydrazinecarbothioamide and 5-bromo-2-hydroxy-3-methoxybenzaldehyde

Afnan Islam and Md Azharul Arafath*

Department of Chemistry, Shahjalal University of Science and Technology, Bangladesh

*Corresponding Author: Md Azharul Arafath, Department of Chemistry, Shahjalal University of Science and Technology, Bangladesh.

Received: August 21, 2023; Published: October 06, 2023


A NSO tridentate Schiff base ligand (E)-2-(5-bromo-2-hydroxy-3-methoxybenzylidene)-N-ethyledrazine-1-carbothioamide (L1) of a new carbothioamide has been synthesized. Co2+ and Ni2+ metal was introduced to tridentate Schiff base ligand to make coordination complexes. Square planar complex of Ni2+ and octahedral complex of Co2+ metal-ions were formed respectively and compounds Na [NiLCl] and Na [CoL(OH2)2Cl] have been found under basic condition. Characterization of these compounds are done by on the basis of melting point, FT-IR spectroscopy and UV-Visible spectroscopy. As the new complexes possesses azomethine(=C=N−) group so they have potential biological activity. For antibacterial study the solution of complexes and ligand was applied against the bacteria S. aureus and B. subtilis to find out their inhibition with bacteria.

Keywords: Thiosemicarbazone; Schiff Base Ligand; Cobalt Complex; Nickel Complex; FT-IR Spectroscopy; UV-Visible Spectroscopy


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Citation: Afnan Islam and Md Azharul Arafath. “Synthesis, Characterization and Anti-bacterial Activity of Co(II) and Ni(II) Complexes with a NSO Donating Site Schiff Base Ligand Derived from N-ethylhydrazinecarbothioamide and 5-bromo-2-hydroxy-3-methoxybenzaldehyde".Acta Scientific Pharmaceutical Sciences 7.11 (2023): 15-21.


Copyright: © 2023 Afnan Islam and Md Azharul Arafath. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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