Nwanama Emmanuel Kenechukwu¹, Ogbo, Felix Ovie², Mbang Joshua Egbe¹* and Mayaki, Esther Oluwatoyin¹

¹Department of Anatomy, Faculty of Basic Medical Sciences, Edo State University, Edo State, Nigeria
²Department of Anatomy, Gregory University Uturu, Abia State, Nigeria
³Department of Anatomy, Faculty of Basic Medical Sciences, University of Calabar, Cross Rivers State, Nigeria

*Corresponding Author: Mbang Joshua Egbe, Department of Anatomy, Faculty of Basic Medical Sciences, University of Calabar, Cross Rivers State, Nigeria

Received: September 05, 2023; Published: September 23, 2022

Abstract

Background:Nephrotoxicity results from an overload of chemicals and drugs including Lead-acetate (Pb), an environmental pollutant. This study examined the nephroprotective potential of Cajanus cajan in male Wistar rats.

Material and Methods: Nephrotoxicity was induced by exposure to Lead at 20mg/kg while Cajanus cajan was administered at 200mg/kg, 400mg/kg and 800mg/kg for 14 days. Markers of nephrotoxicity including urea and serum creatinine were evaluated, and histoarchitecture alteration of the tissue was examined.

Results: The lead exposed group showed a marginal increase in urea and serum creatinine significantly (p < .05) compared to control values. The Cajanus cajan-treated groups showed a significant (p < .05) decrease respectively in urea and serum creatine. Cajanu cajan protected kidney tissue morphology.

Conclusion: The results indicate that Cajanus cajan protected Kidneys against Lead-induced toxicity

Keywords: Microplastic; Ocean Water; Surface Water; Drinking Water; Aquatic Ecosystem; Human Health

References

1. Mohamed R S., et al. “Hepatorenal protective effect of flaxseed protein isolate incorporated in lemon juice against lead toxicity in rats”. Toxicology Reports 7 (2020): 30-35.
2. Gargouri M., et al. “Protective effects of spirulina against hemato-biochemical alterations, nephrotoxicity, and DNA damage upon lead exposition”. Human and Experimental Toxicology6 (2020): 855-869.
3. Salama S A., et al. “Gamma-glutamyl cysteine attenuates tissue damage and enhances tissue regeneration in a rat model of lead-induced nephrotoxicity”. Biological Trace Element Research1 (2016): 96-107.
4. Harari F., et al. “Blood lead levels and decreased kidney function in a population-based cohort”. American Journal of Kidney Diseases 3 (2018): 381-389.
5. Liu C M., et al. “Puerarin protects rat kidney from lead-induced apoptosis by modulating the PI3K/Akt/eNOS pathway”. Toxicology and Applied Pharmacology3 (2012a): 330-342.
6. Gautam P and Flora S J S. “Oral supplementation of gossypin during lead exposure protects alteration in heme synthesis pathway and brain oxidative stress in rats”. Nutrition 5 (2010): 563-570.
7. Jiang S., et al. “In vitro and in vivo toxic effects and inflammatory responses induced by carboxylated black carbon-lead complex exposure”. Ecotoxicology and Environmental Safety 165 (2018): 484-494.
8. Sudjarwo SA., et al. “The potency of chitosan-Pinus merkusii extract nanoparticle as the antioxidant and anti-caspase 3 on lead acetate-induced nephrotoxicity in rat”. Advanced Pharmaceutical Technology and Research 1 (2019): 27-32.
9. Rahmi E P., et al. “Anti-hyperuricemic and anti-inflammatory effects of Marantodes pumilum as potential treatment for gout”. Frontiers in Pharmacology 11 (2020): 289.
10. Choy KW., et al. “Flavonoids as natural anti-inflammatory agents targeting nuclear factor-kappa B (NFkappaB) signaling in cardiovascular diseases: A mini review”. Frontiers in Pharmacology 10 (2019): 1295.
11. Wang SW., et al. “The flavonoid-rich fraction from rhizomes of Smilax glabra Roxb. ameliorates renal oxidative stress and inflammation in uric acid nephropathy rats through promoting uric acid excretion”. Biomedicine and Pharmacotherapy 111 (2019): 162-168.
12. Zavinon F., et al. “Pigeon pea [Cajanus cajan (L.) Millsp] cultivation, its major constraints and ethnobotanical status in Southern Benin”. Journal of Agricultural 7 (2019): 95-105.
13. Hayat K., et al. “Ameliorative Effects of Exogenous Proline on Photosynthetic Attributes, Nutrients Uptake, and Oxidative Stresses under Cadmium in Pigeon Pea (Cajanus cajan L.)”. Plants 10 (2021): 796.
14. Maha Z Rizk., et al. “Hepatoprotective effect of Caesalpinia gilliesii and Cajanus cajan proteins against acetoaminophen overdose-induced hepatic damage”. Toxicology and Industrial Health5 (2016): 877-907.
15. Evbakhavbokun W O and Iweala EJ Emeka. “Protective Effect of Cajanus cajan in Hepatotoxic Rats”. Earth and Environmental Science 331 (2019): 012023.
16. Ogbu CO., et al. “Hepatoprotective Potentials of Ethanolic Leaf Extract of Cajanus cajan (linn) in Ethanol-evoked Oxidative Stress in Albino Rats”. IRJGH 2 (2022): 1-6.
17. Wang Q., et al. “Spectroscopy characterization, theoretical study and antioxidant activities of the flavonoids-Pb (II) complexes”. Journal of Molecular Structure 1209 (2020): 127919.
18. Aladaileh S H., et al. “Spirulina platensis ameliorates the sub chronic toxicities of lead in rabbits via anti-oxidative, anti- inflammatory, and immune stimulatory properties”. Science of The Total Environment 701 (2020): 134879.
19. Adhikari A., et al. “Spectroscopic studies on dual role of natural flavonoids in detoxification of lead poisoning: Bench-to-bedside preclinical trial”. ACS Omega11 (2018): 15975-15987.
20. Ravipati E S., et al. “The toxicological effects of lead and its analytical trends: an update from 2000 to 2018”. Critical Reviews in Analytical Chemistry (2019): 1-16.
21. Gargouri M., et al. “Potential protective effects of the edible alga Arthrospira platensis against lead-induced oxidative stress, anemia, kidney injury, and histopathological changes in adult rats”. Applied Physiology, Nutrition, and Metabolism 3 (2019): 271-281.
22. Shirpoor A., et al. “Ginger extract protects rat’s kidneys against oxidative damage after chronic ethanol administration”. Biomedicine and Pharmacotherapy 84 (2016): 698-704.
23. Vicente-Vicente L., et al. “Quercetin, a promising clinical candidate for the prevention of contrast-induced nephropathy”. International Journal of Molecular Sciences19 (2019): 4961.

Citation

Citation: Mbang Joshua Egbe., et al. “Histomorphology and Nephroprotective Effect of Cajanus cajan in Lead-acetate-Induced Kidney Damage". Acta Scientific Pharmaceutical Sciences 7.10 (2023): 56-60.

Copyright

Copyright: © 2023 Mbang Joshua Egbe., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.