Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 7 Issue 9

Comparative Study on the Effect of Trypanosoma Brucei Infections on the Kidney Functionality and Chemotherapeutic Interventions in Dogs. A Case Study of Diminazene Aceturate and Isometamidium Chloride.

Akpa PO1* and Ukwueze CS2

1Department of Veterinary Medicine, University of Nigeria, Nsukka Nigeria
2Department of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, Nigeria

*Corresponding Author: Akpa PO, Department of Veterinary Medicine, University of Nigeria, Nsukka Nigeria.

Received: June 30, 2023; Published: August 21, 2023


The kidney functionality of twenty growing Nigerian dogs (Mongrel) of both sexes weighing between 3.0-8.0 kg were used to assess the kidney function following infection with Trypanosoma brucei (T. brucei) and the comparative efficacy of diminazene aceturate (DA), and Isometamidium chloride (IMC)on the damage infection could cause if any by T. brucei. The purpose of the work was to find out which of the trypanocides (DA and IMC) can better reverse the kidney function parameters studied, following infection. The dogs were randomly assigned into four groups (1-4) with five dogs per group as follows: 1= infected and treated with DA (7.0mg/kg; 2= uninfected untreated; 3= infected and not treated with either of the trypanocides; 4= trypanosome infected and treated with IMC (0.5 mg/kg). Diminazene aceturate (DA) and isometamidium chloride (IMC) were able to eliminate the parasites from the blood stream. However, relapse of infection was observed in two of the dogs from group 1 and one dog in group 4 by days 35 and 56 post infection (PI), none of the treated dogs died following relapse of infection except one dog from group 1. The infection caused a significant increase (p<0.05) in the mean blood urea nitrogen (BUN) by 21 post infection (PI), whereas the infection caused a significant increase in the mean creatinine (Cr) by days 14 and 21 PI when compared with the normal control (group 2). However, by day 49 PI and beyond, BUN was significantly higher in group 4 (IMC- treated) when compared to the normal control, unlike group 1 (DA- treated) which was similar to the normal control. The findings suggested that DA-treated satisfactorily reversed BUN and Cr to normal; unlike IMC which could not reverse the BUN satisfactorily, but reversed Cr to normal value satisfactorily.

Keywords: Dogs; Diminazene Aceturate; Isometamidium Chloride; Kidney Function; Trypanosoma Brucei


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Citation: Akpa PO and Ukwueze CS. “Comparative Study on the Effect of Trypanosoma Brucei Infections on the Kidney Functionality and Chemotherapeutic Interventions in Dogs. A Case Study of Diminazene Aceturate and Isometamidium Chloride.". Acta Scientific Pharmaceutical Sciences 7.9 (2023): 32-38.


Copyright: © 2023 Akpa PO and Ukwueze CS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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