Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 7 Issue 9

Forced Degradation Studies for Estimation of Finerenone by RP-HPLC Method

Janga Rameshbabu*, Sunkara Sivaprasad, Battula Sowjanya Lakshmi and Suryadevara Vidyadhara

Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, India

*Corresponding Author: Janga Rameshbabu, Professor and H.O.D, Department of Pharmaceutics, Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Guntur, India.

Received: June 19, 2023; Published: August 19, 2023


The goal of a sustained release dosage form is to maintain therapeutic blood or tissue levels of the drug for an extended and specified period of time. The aim of this study was to formulate and evaluate sustained release microspheres of Venlaflaxin Hydrochloride. Sustained release microspheres were obtained by solvent evaporation method for all the formulations from F1 to F9. Formulations F1, F2 and F3 were prepared Venlafaxine HCl with Chitosan polymer in the ratio of 1: 1, 1: 2 and 1: 3.Formulations F4, F5 and F6 were prepared Venlafaxine HCl with Sodium alginate polymer in the ratio of 1:1, 1:2 and 1:3; and formulations F7, F8 and F9 were prepared Venlafaxine HCl with Xanthan gum polymer in the ratio of 1: 1, 1: 2 and 1: 3 respectively: Based on the in vitro drug release characteristics and entrapment efficiency, the formulation F3 was found to be best formulation. By increasing the concentration of polymer, decreased the rate of drug released. According to stability study it was found that there was no variation in Percentage yield, Entrapment efficiency, and in vitro drug released profile of selected formulation F3 at specified period. Drug and Polymer interaction for formulated SR microsphere embedded on Venlaflaxin Hydrochloride was characterized by FT-IR and DSC studies.: The result showed that there is no interaction between the drug and polymer. Surface morphology of formulation carried out by SEM showed good spherical geometry and uniformity in size and shape. The formulation F3 was concluded best formulation among the prepared formulations.

 Keywords: Microspheres; Drug Loading; Venlaflaxin Hydrochloride; Drug Release; Sustained Release


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Citation: Janga Rameshbabu., et al. “Design, Characterisation and Evaluation of Venlafaxine Hydrochloride Sustained Release Microspheres". Acta Scientific Pharmaceutical Sciences 7.9 (2023): 42-50.


Copyright: © 2023 Janga Rameshbabu., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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