Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 7 Issue 6

Recombinant Apolipoprotein A-I Is Able Bind and Transport Doxorubicin into Ehrlich Carcinoma Cells

Roman A Knyazev1*, Alexander V Ryabchenko1, Wu Naishi2, Maria V Kotova, Natalia V Trifonova1, Lev M Polyakov1 and Mikhail I Voevoda1

1Federal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia
2The Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, China

*Corresponding Author: Roman A Knyazev, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.

Received: May 02, 2023; Published: May 26, 2023

Abstract

The study tries to solve the problem related to the development of new transport forms of anticancer drugs.

The methods of fluorescence quenching and gel filtration have shown that the recombinant apolipoprotein A-I obtained by us has the ability to form a stable complex with doxorubicin. The calculated value of the association constant of the complex confirms the possibility of using the recombinant аpolipoprotein A-I as a transport form into tumor cells. The number of molecules of the anticancer drug bound per protein molecule represents a wide range of dosage adjustment. Proven ability of recombinant apolipoprotein A-I c doxorubicin penetrate into cytoplasm and nucleus of Ehrlich ascites carcinoma cells.

The results obtained make it possible to consider the real possibility of using recombinant apolipoprotein A-I as a transport form of doxorubicin.

 Keywords: Recombinant Apolipoprotein A-I; Transport form of Anticancer Drugs; Ehrlich's Ascites Carcinoma; Chemotherapy; Doxorubicin

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Citation

Citation: Roman A Knyazev., et al. “Recombinant Apolipoprotein A-I Is Able Bind and Transport Doxorubicin into Ehrlich Carcinoma Cells". Acta Scientific Pharmaceutical Sciences 7.6 (2023): 48-54.

Copyright

Copyright: © 2023 Roman A Knyazev., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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