Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Case Report Volume 7 Issue 6

Myelodysplastic Syndrome with Complex Cytogenetics Converted into Acute Myeloid Leukemia within Short Duration, Case Reported in Tertiary Care Hospital Karachi, Pakistan

Arifa Aziz1* and Iffat Shehzad2

1Staff Medical Officer, Supervisor at Day Care Oncology, Department of Oncology, Aga Khan University Hospital, Pakistan
2Medical Officer, Day Care Oncology, Department of Oncology, Aga Khan University Hospital, Pakistan

*Corresponding Author: Arifa Aziz, Staff Medical Officer, Supervisor at Day Care Oncology, Department of Oncology, Aga Khan University Hospital, Pakistan.

Received: May 05, 2023; Published: May 24, 2023

Abstract

Introduction: 36 years old male presented with low-grade fever for two months and occasional night sweats, diagnosed as myelodysplastic syndrome after complete workup.

Method: All base line investigations were done including complete blood count, Liver function test, Renal function test, hepatitis B and C and bone marrow aspirate and trephine.

Result: After receiving appropriate treatment which turn out to be nonresponsive and myelodysplastic Syndrome (MDS) is converted into acute myeloid leukemia within short duration and with treatment which is very rare.

 Keywords: Myelodysplastic Syndrome; Acute Myeloid Leukemia; Bone Marrow

References

  1. "Myelodysplastic Syndromes". NORD (National Organization for Rare Disorders) (2019).
  2. Hatnagar N., et al. "Transient Abnormal Myelopoiesis and AML in Down Syndrome: an Update". Current Hematologic Malignancy Reports5(2016): 333-341.
  3. Silverman LR., et al. "Further analysis of trials with azacitidine in patients with myelodysplastic syndrome: studies 8421, 8921, and 9221 by the Cancer and Leukemia Group B". Journal of Clinical Oncology24 (2006): 3895-903.
  4. Cutler CS., et al. "A decision analysis of allogeneic bone marrow transplantation for the myelodysplastic syndromes: delayed transplantation for low-risk myelodysplasia is associated with improved outcome". Blood 2 (2004): 579-585.
  5. Berneman ZN., et al. "A myelodysplastic syndrome preceding acute lymphoblastic leukaemia”. British Journal of Haematology 60 (1985): 353-354.

Citation

Citation: Arifa Aziz and Iffat Shehzad. “Myelodysplastic Syndrome with Complex Cytogenetics Converted into Acute Myeloid Leukemia within Four Months, Case Reported in Tertiary Care Hospital Karachi, Pakistan". Acta Scientific Pharmaceutical Sciences 7.6 (2023): 35-36.

Copyright

Copyright: © 2023 Arifa Aziz and Iffat Shehzad. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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