Ajesh Kumar A*, Syed Abuthahir SS and Syed Ali Padusha M

Department of Chemistry, Jamal Mohamed College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India

*Corresponding Author: Syed Abuthahir SS, Department of Chemistry, Jamal Mohamed College (Autonomous), Affiliated to Bharathidasan University, Tiruchirappalli, Tamil Nadu, India.

Received: April 18, 2023; Published: May 08, 2023

Abstract

The development of anti-inflammatory medications that target NF-κB has received a lot of attention because NF-κB activation is also strongly linked to inflammatory illnesses. Therefore, the goal of the current study is to examine the anti-inflammatory properties of Areca catechu L. nut extract. The stability of the red blood cell membrane, in silico analysis, and in vitro denaturation of albumin were all investigated. An anti-inflammatory impact on albumin denaturation inhibition and HRBC membrane stability at 1000 g/mL, comparatively low IC₅₀ value than normal, was seen in preliminary investigations utilising a single dose (10 mg/ml) of Areca catechu L. nut and its corresponding component arecoline. Arecoline's additional affinity for nuclear kappa factor B. These findings support the medical use of Areca catechu L. nut in inflammatory illnesses by demonstrating its anti-inflammatory.

 Keywords: In-vitro; In-silico; Anti-inflammatory; Arecoline; NF-κB; Albumin Denaturation Inhibition; HRBC

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Citation

Citation: Ajesh Kumar A., et al. “In-vitro and In-silico Studies on the Anti-inflammatory Properties of Arecoline from Areca catechu L. Nut". Acta Scientific Pharmaceutical Sciences 7.6 (2023): 03-08.

Copyright

Copyright: © 2023 Ajesh Kumar A., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.