Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Case Review Volume 7 Issue 5

Cocrystals: A New Form of Solid with Improved Physico-chemical Properties

RR Thenge*

Dr. Rajendra Gode College of Pharmacy, Malkapur, Maharashtra, India

*Corresponding Author: RR Thenge, Dr. Rajendra Gode College of Pharmacy, Malkapur, Maharashtra, India.

Received: February 27, 2023; Published: April 24, 2023

Abstract

Co-crystals are defined as structurally homogeneous/heterogeneous crystalline solids that include drug and coformer in specific stoichiometric proportions. The discrete neutral molecular reactants that make up co-crystals are solids at room temperature. According to this definition of co-crystals, a pharmaceutical co-crystal is a mixture in which one of the co-crystals’ elements serves as an active medicinal ingredient and the other elements serve as coformers. An active drug hydrate is not a co-crystal, as is evident from the statement, but a solid-state drug hydrate is co-crystalline with a coformer to produce a co-crystal [1]. The pharmaceutical sector currently places a lot of attention on co-crystal methods. Pharmaceutical co-crystals can successfully enhance the drug substance’s solubility, dissolving profile, bioavailability and physical stability, in addition to other crucial features such as flowability, chemical stability, compressibility and hygroscopicity [2].

References

  1. Torchilin V. “Micellarnano carriers: Pharmaceutical perspectives”. Pharmacy Research 24 (2007): 1-16.
  2. Yue X., et al. “Amphiphilic methoxy poly (ethylene glycol)-b-poly (-caprolactone)-b-poly (2-dimethylaminoethyl methacrylate) cationic copolymer nanoparticles as a vector for gene and drug delivery”. Biomacromolecules 11 (2010): 2306-2312.
  3. Horst JH., et al. “Discovering new Co-crystals”. Crystal Growth and Design 9 (2009): 1531-1537.
  4. Alhalaweh A and Velaga P. “Formation of Co-crystals from stoichiometric solutions of incongruently saturating systems by spray drying”. Crystal Growth and Design8 (2010): 3302-3305.
  5. Braga D and Grepioni F. “Reactions between or within molecular crystals”. Chemical International. Edition31 (2004): 4002-4011.
  6. Jung M-S., et al. “Bioavailability of indomethacin– saccharin cocrystal”. Journal of Pharmaceutical Pharmacology 62 (2010): 1560-1568.
  7. Dai XL., et al. “Improving the membrane permeability of 5-fluorouracil via Cocrystallization”. Crystal Growth and Design8 (2016): 4430-4438.
  8. Pagire SK., et al. “Thermodynamic investigation of CarbamazepineSaccharin Co-crystal polymorphs”. Journal of Pharmaceutical Science 106 (2017): 2009-2201.
  9. Bethune SJ., et al. “Understanding and predicting the effect of cocrystal components and pH on cocrystal solubility”. Crystal Growth and Design 9 (2009): 3976-3988.
  10. Verma S., et al. “Improvement of solubility and bioavailability of aceclofenac using cocrystallization”. Drug Invention Today1 (2019): 59-63.
  11. Sanphui P., et al. “Fast dissolving curcumin co-crystals”. Crystal Growth and Design9 (2011): 4135-4145.
  12. Newman A and Wenslow R. “Solid form changes during drug development: Good, bad, and ugly case studies”. AAPS Open1 (2016).

Citation

Citation: RR Thenge. “Cocrystals: A New Form of Solid with Improved Physico-chemical Properties". Acta Scientific Pharmaceutical Sciences 7.5 (2023): 20-21.

Copyright

Copyright: © 2023 RR Thenge. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US