Anandteerth Deshpande*, Venkatesan Natarajan and Boguda Anantharamaiah Vishwanath

Aditya Bangalore Institute of Pharmacy Education and Research, Bangalore, Karnataka, India

*Corresponding Author: Anandteerth Deshpande, Aditya Bangalore Institute of Pharmacy Education and Research, Bangalore, Karnataka, India.

Received: September 21, 2022; Published: December 14, 2022

Abstract

The current study's objective was to determine how active fractions from Allmania nodiflora leaves affected the lipid and serum glucose profiles in normal and diabetic rats. Streptozotocin (45 mg/kg) activated diabetes in wistar rats. Ethanolic extract of Allmania nodiflora (EEAN) leaf was given orally at doses of 200 and 400 mg/kg.p.o. Metformin (50 mg/kg p.o.) was administered as the usual anti-diabetic medication. When compared to normal control rats, EEAN considerably (p < 0.05) decreased the fasting blood glucose (FBG) level. In addition, column chromatography was used to isolate an active compound, which was given the innocuous name AN-1. A study of the hypoglycemic and hypolipidemic effects of AN-1 (100 mg/kg) was conducted. In diabetic rats, AN-1 significantly (p < 0.05) decreased FBG levels while simultaneously lowering cholesterol and triglycerides and raising HDL levels. This finding suggests that AN-1 has demonstrated anti-diabetic and anti-hyperlipidemic activity, and it offers a rational scientific justification for the use of anti-diabetic medications.

Keywords: Blood Glucose; Allmania nodiflora; Lipid Profile; GC-MS

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Citation

Citation: Anandteerth Deshpande., et al. “Effect of Active Fraction Isolated from the Leaf Extract of Allmania nodiflora on Plasma Glucose Concentration and Lipid Profile in Streptozotocin-Induced Diabetic Rats". Acta Scientific Pharmaceutical Sciences 7.1 (2023): 08-13.

Copyright

Copyright: © 2022 Anandteerth Deshpande., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.