Nidhi Ranawat¹*, Shreshtha Tiwari², Animesh Choudhary³, Sandeep Ojha⁴, Shishir Agarwal⁵, Ashish Mazumdar⁶ and Jayesh Sharma⁷

¹Clinical Biochemist, Department of Laboratory Medicine, BALCO Medical Centre, Raipur (Chhattisgarh), India
²Consultant, Microbiology and Infection Control Officer, Department of Laboratory Medicine, BALCO Medical Centre, Raipur (Chhattisgarh), India
³Associate Professor, Raipur Institute of Medical Sciences, Raipur (Chhattisgarh), India
⁴Consultant and Head Pathology, Department of Laboratory Medicine, BALCO Medical Centre, Raipur (Chhattisgarh), India
⁵Junior Consultant, Radiology, BALCO Medical Centre, Raipur (Chhattisgarh), India
⁶Senior Consultant and Head of Department, Anaesthesiology, Critical care Pain and Palliative Care, BALCO Medical Centre, Raipur (Chhattisgarh), India
⁷Chief of Medical Services, Sr. Consultant, Surgical Oncology, Department of Surgical Oncology, BALCO Medical Centre, Raipur (Chhattisgarh), India

*Corresponding Author: Nidhi Ranawat, Clinical Biochemist, Department of Laboratory Medicine, BALCO Medical Centre, Raipur (Chhattisgarh), India.

Received: November 01, 2022; Published: November 15, 2022

Abstract

Objectives: To correlate Serum LDH levels with severity of COVID 19, and establish LDH as potential marker for COVID 19 prognosis and treatment.

Materials and Method: The study is performed in 204 confirmed COVID 19 cases at a dedicated COVID care Hospital. Lab investigations including Serum LDH, Ferritin, CRP, and D-dimer were estimated at the time of patient admission. The patients were divided into 2 groups namely severe and non-severe based on WHO guidelines. The values for these parameters were compared and the sensitivity and specificity of every parameter was analysed concerning COVID-19 severity and mortality.

Statistical Analysis: Unpaired t-test was used for statistics between the severe and non-severe groups followed by ROC analysis for LDH, CRP, Ferritin, and D-dimer.

Results: The levels of LDH, CRP, and D-dimer were raised in the patients in the severe group as compared to the non-severe group with a significant p-value of < 0.05. Also in ROC analysis the sensitivity and specificity of LDH were found to be good for CRP, Ferritin, and D-dimer. Also, it was observed that among 204 patients, 29 patients died due to COVID, and their serum LDH values were found to be increased which was not the case in the other 3 parameters.

Conclusions: LDH was a better marker in predicting the Severity of COVID-19 disease, also its value is highly significant in predicting the mortality of patients at the time of admission which can help in early prognosis and help in the clinical management of the patient.

Keywords: LDH; COVID 19; Severity

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Citation

Citation: Nidhi Ranawat., et al. “Role of LDH in Predicating the Severity and Mortality in COVID-19 Patients in Comparison to Other Laboratory Markers at the Time of Admission". Acta Scientific Pharmaceutical Sciences 6.12 (2022): 20-24.

Copyright

Copyright: © 2022 Nidhi Ranawat., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.