Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Short Communication Volume 6 Issue 11

Organophosphorous Poisoning - A Plausible Herbal Antidote from the Dry Leaf Powder of Sesbania grandiflora L

V Amalan Stanley1*, Thangavel Kumar2 and Shaleesha A Stanley3

1Scientific and Academic Board, International Institute of Biotechnology and Toxicology, Kancheepuram District, Tamil Nadu, India
2Director, Palamur Biosciences Pvt Ltd, Secunderabad, Telangana, India
3Professor and Head, Jeppiaar Engineering College, Sholinganallur, Chennai, India

*Corresponding Author: V Amalan Stanley, Scientific and Academic Board, International Institute of Biotechnology and Toxicology, Kancheepuram District, Tamil Nadu, India.

Received: October 17, 2022; Published: October 31, 2022


Organophosphorus compounds (OPCs) are one of the major agrochemicals extensively used for crop protection and insect control worldwide. As the compounds are most toxic leading to increased poisoning especially among the spray persons severe restrictions and control measures of using them has been practised. There are a few antidotes developed exclusively for the poisoning of OPCs. With this status quo, an experimental pilot study was conducted to develop an herbal antidote for the OPC poisoning using the dry leaf powder extract of Sesbania grandiflora L. The leaves of the plant has already been proven to have many medicinal properties in terms of Indian System of Medicines, particularly its anticonvulsant, antiepileptic and anxiolytic activities in rodent models. Based on these scientific information a short term fourteen day pilot study was conducted where pesticide (Chlorphyriphos EC) exposed rodents were simultaneously treated with the leaf extract. At the end of the study, the analysis of brain samples of the treated and control groups for acetylcholine revealed a biologically significant sign of recovery among the treated animals in comparison with the control group. The levels of acetylcholine (AChE) in the herbal treated group of pesticide exposed animals remained comparable with the control group of animals, confirming the prospective antidotal potential of the leaf extract of S. grandiflora for the treatment of chronic OPC poisoning. This is hoped to serve particularly the agricultural people living in the remote rural areas where immediate health care and support systems are inaccessible in time.

Keywords: Organophosphorus Compounds (OPCs); S. grandiflora; Leaf


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Citation: V Amalan Stanley., et al. “Organophosphorous Poisoning - A Plausible Herbal Antidote from the Dry Leaf Powder of Sesbania grandiflora L". Acta Scientific Pharmaceutical Sciences 6.11 (2022): 28-30.


Copyright: © 2022 V Amalan Stanley., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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