Anil Kumar Kota and Mukthinuthalapati Mathrusri Annapurna*

Department of Pharmaceutical Analysis, GITAM School of Pharmacy, Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, India

*Corresponding Author: Mukthinuthalapati Mathrusri Annapurna, Department of Pharmaceutical Analysis, GITAM School of Pharmacy, Gandhi Institute of Technology and Management (Deemed to be University), Visakhapatnam, India.

Received: September 30, 2022; Published: October 17, 2022

Abstract

Perindopril erbumine is used for the treatment of heart failure, hypertension and other coronary artery diseases. A new stability indicating RP-UFLC method has been proposed for the estimation of Perindopril erbumine in tablet dosage forms. A mixture of 10 mM Tetra butyl ammonium hydrogen sulphate (pH 3.4): Acetonitrile: 0.1% Acetic acid (48:52: 0.1) was chosen as mobile phase (Isocratic mode) with flow rate 0.8 mL/min (Detection wavelength 210 nm). Shimadzu Model UFLC system with PDA detector and Luna C8 Column was used for the study. Perindopril erbumine obeys Beer-Lambert’s law over the concentration range 0.2-120 µg/mL with linear regression equation y = 47597x – 10133 (R² = 0.9999). The LOQ and LOD were found to be 0.1981 µg/mL and 0.0641 µg/mL. Stress degradation studies were performed such as acid hydrolysis, alkaline hydrolysis, thermal treatment and oxidation according to the ICH guidelines. The proposed UFLC method has validated and found to be simple, precise, accurate, robust and is very much useful for the analysis of pharmaceutical formulations (Tablets).

Keywords: Perindopril Erbumine; RP-UFLC; Stability Indicating; Validaion; ICH Guidelines

References

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Citation

Citation: Anil Kumar Kota and Mukthinuthalapati Mathrusri Annapurna. “A New Stability Indicating RP-UFLC Method for the Estimation of Perindopril Erbumine Tablet Dosage Forms". Acta Scientific Pharmaceutical Sciences 6.11 (2022): 03-10.

Copyright

Copyright: © 2022 Anil Kumar Kota and Mukthinuthalapati Mathrusri Annapurna. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.