Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Editorial Volume 6 Issue 11

Naturally Occurring Cyclic Peptides as HDAC Inhibitors

Uttam Ghosh1* Goutam Ghosh2*

1Department of Chemistry, University of Nevada, Reno, Virginia Street, Reno, NV, USA
2Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Münster, Germany

*Corresponding Author: Uttam Ghosh and Goutam Ghosh, Department of Chemistry, University of Nevada, Reno, Virginia Street, Reno, NV, USA and Organisch-Chemisches Institut, Westfälische Wilhelms-Universität, Münster, Germany.

Received: September 23, 2022; Published: October 01, 2022

The term cancer is used to describe a group of over 100 different diseases all of which have a similar characteristic about them: the out-of-control abnormal growing of cells. Every sixth death in the world is due to cancer, making it the second leading cause of death (second to cardiovascular diseases). Thus, the need for new cancer therapies is also on the rise. It has been shown that histone deacetylases (HDACs) are over expressed in cancer tissues and therefore, inhibiting them is considered to be a way to slow down the progression or stop the spread of cancer in the body.

References

  1. J F Couture and R C Rievel. Current Opinion in Structural Biology 16 (2006): 753-760.
  2. G P Delcuve., et al. “Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors”. Clinical Epigenetics 4 (2012): 5-8.
  3. M Yoshida., et al. “Trichostatin A and trapoxin: novel chemical probes for the role of histone acetylation in chromatin structure and function”. Bioessays 17 (1995): 423-430.
  4. S C Mwakwari., et al. “Macrocyclic histone deacetylase inhibitors”. Current Topics in Medicinal Chemistry 10 (2010): 1423-1440.
  5. R Furumai., et al. “Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin”. Proceedings of the National Academy of Sciences of the United States of America 98 (2001): 87-92.

Citation

Citation: Uttam Ghosh Goutam Ghosh. “Naturally Occurring Cyclic Peptides as HDAC Inhibitors". Acta Scientific Pharmaceutical Sciences 6.11 (2022): 01-02.

Copyright

Copyright: © 2022 Uttam Ghosh Goutam Ghosh. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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