Sushant Kumar¹*, Swarnima Pandey² and Anita Singh³

¹Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India
²Department of Pharmacy, Hygia Group of Institutions, UP, India
³Research Associate, Dr. SK Research and Development laboratory, Dewa, UP, India

*Corresponding Author: Sushant Kumar, Faculty of Pharmacy, Uttar Pradesh University of Medical Sciences, Saifai, Etawah, Uttar Pradesh, India.

Received: July 28, 2022; Published: August 22, 2022

Abstract

The aim of this research was to isolate and characterize the novel biopolymer from Phaseolus vulgaris seeds. The biopolymer was isolated by simplified and economical process and analysed for different physico-chemical and spectral properties. The isolated biopolymer appears as free flowing powder. The isolation procedures were optimized by repeating it for six times and thus were found to be economical and reproducible in nature. The different functional groups like presence of hydroxyl, alkanes and alkenes, carboxylic acid which confirms its polymeric nature. The other groups like aromatic ring at, ketone were found to be present in the FTIR spectra, NMR and mass spectra. The study finds that the isolated biopolymer from Phaseolus vulgaris seeds contains unusual inherent stabilizer and cum retardant capabilities that can be exploited to develop a lamotrigine-loaded bionanosuspension for long-term administration of drug candidate.

Keywords: Biopolymer; Biomaterial; SEM; Mass Spectra; FTIR Spectra; Economical

References

1. Tangri P and Satheesh Madhav NV. “Formulation and evaluation of zidovudine bio-micro dwarfs using a novel bio muco resident from Artocarpus heterophyllus”. International Journal of PharmTech Research 3 (2011): 169-174.
2. Shankar MSU and Madhav NVS. “A novel smart mucoadhesive biomaterial from Lallimantia royalena seed coat”. Journal of Science Asia 37 (2011): 69-71.
3. Madhav NVS and Pangatey P. “Development of flexy bio- adhesive film loaded with nanosized zidovudine for brain specificity via novelistic soft palatal route”. Indian Patent (2013).
4. Satheesh Madhav NV and Tangri P. “Design and evaluation of insulin loaded Bio- Flexy films for trans-soft palatal to brain delivery”. 4 (2012): 10-18.
5. Satheesh Madhav NV and Yadav AP. “Development and evaluation of novel repaglinide biostrips for translabial delivery”. International Research Journal of Pharmacy 4 (2013): 198-202.
6. Ojha A and Satheesh Madhav NV. “A novel potent muco- bioadhesant polymer from seeds of Ricinus communis”. World Journal of Pharmaceutical Sciences 3 (2014): 2154-2165.
7. Satheesh Madhav N V and Yadav AP. “A novel translabial platform utilizing bioexcipients from Litchi chinensis for the delivery of rosiglitazone maleate”. Acta Pharmaceutica Sinica B 3 (2013): 408-415.
8. “Nanosuspensions as particulate drug formulation in therapy rationale for development and what we can expect for the future”. Advanced Drug Delivery Reviews 47 (2001): 3-19.
9. Rogawski MA and Loscher W. “The neurobiology of antiepileptic drugs”. Nature Reviews Neuroscience 553-564.
10. Zhang J. “Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants”. International Journal of Pharmaceutics 323 (2006): 153-163.
11. Patsalos PN., et al. “The importance of drug interactions in epilepsy therapy”. Epilepsia 43 (2002): 365-385.
12. Dawood NM. “Formulation and characterization of lafutidine nanosuspension for oral drug delivery system”. International Journal of Applied Pharmaceutics 10 (2018): 20-30.
13. Madhav S and Singh K. “Smart ungual biopenetrant from the roots of Beta vulgaris”. Journal of Applied Pharmaceutical Research 2 (2017): 21-26.
14. Martin A. “Physical, Chemical Principles in the Pharmaceutical Sciences”. 3^rd Varghese Publishing House, Bombay (2001).
15. Subrahmanyam CVS and Thimma Setty J. “Laboratory Manual of Physical Pharmaceutics”. 2^nd Vallabh Prakashan, New Delhi (2002).
16. Kamila SN., et al. “Evaluation of effective Medhya formulation on trancranial treatment on rat”. International Journal of Biomedical Research 6 (2014): 427-431.
17. Tyagi Y and Madhav NVS. “Design selegiline loaded bio-nanosuspension for the management of depression using novel bio-retardent from Manilkara zapota”. Drug Development and in Industrial Pharmacy 45 (2019): 1351-1360.
18. Madhav NVS and Singh B. “A smart approach for delivering of nanosized olanzapine using piper betel biopolymer rate controlling flexi films for transvermillion delivery”. Asian Journal of Nanoscience and Materials 2 (2019): 314-326.
19. Madhav NVS and Raina D. “Formulation and evaluation of duloxetine loaded bio-nanosuspension for brain specificity via acoustic meatus”. SOJ Pharmacy and Pharmaceutical Science1 (2017): 1-5.
20. Varshney S and Madhav NVS. “Smart approach for preparing nanosized topiramate loaded bio-flexy films using former from piper nigrum and screening its In-vitro performance”. Nanomedicine and Nanotechnology3 (2018): 000147.

Citation

Citation: Sushant Kumar., et al. “Isolation and Characterization and Cell-line Toxicity Study of Novel Biopolymer from Naturally Occurring Seeds". Acta Scientific Pharmaceutical Sciences 6.9 (2022): 17-22.

Copyright

Copyright: © 2022 Sushant Kumar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.