Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Review Article Volume 6 Issue 8

Microspheres: The Efficient Controlled Drug Delivery Carriers

Jayprakash Prajapati, Shashi Kiran Misra*, Swarnakshi Upadhyay and Anupriya Kapoor

School of Pharmaceuticals Sciences, C.S.J.M. Kanpur, (UP.), India

*Corresponding Author: Shashi Kiran Misra, Associate Professor, School of Pharmaceuticals Sciences, C.S.J.M. Kanpur, (UP.), India.

Received: June 29, 2022; Published: July 29, 2022

Abstract

Microspheres, free-flowing solid powders are generally made up of biodegradable and biocompatible polymers. Oral, parental, nasal, Ocular, transdermal, colonel, and other routes can be used to administer microspheres with particle sizes ranging from 0.1 to 200 micrometer. Microspheres play a totally vital position as particulate drug transport machine due to their small length and different green properties. Microspheres had been proved to be a appropriate bridge to scale the gap over to formulate an powerful dosage form, to simulate managed drug release. Numerous recent advancements in microspheres, such as mucoadhesive, hollow, magnetic and floating have contributed to overcoming the various challenges connected with their usage such as site specific targeting and enhanced release kinetics. Microspheres will play a key role in novel drug delivery in the future, thanks to a combination of new methodologies, particularly in sick cell sorting, genetic materials, and safe, targeted, and effective drug delivery. Oral modified release microspheres have always proven to be a more effective treatment option than single-unit dosage forms that are released immediately. Multi-particulates are commonly formed into microspheres and filled into hard gelatin capsules as the final dose form. Microspheres have attracted a lot of interest, not just for their long term. It can be used now not excellent for release but moreover for drug targeting. Microspheres will play an increasingly more crucial characteristic in future drug delivery, especially in ailment treatment, diagnosis, genetic material, and targeted effective drug delivery.

Keywords: Microspheres; Controlled Release; Biodegradable; Biocompatible; Modified Release

References

  1. Sachine E., et al. “Formulation and Development of Repaglinide Microparticles by Ionotropic Gelation Technique”. Indian Journal of Pharmaceutical Education and Research 47 (2006): 777-780.
  2. Diane J., et al. “Dept of pharmaceutical sciences, University of Connecticut, Storrs, Connecticut, U.SA”. Anthony J Hickey, Dept of Pharmaceutics, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, U.S.A (Encyclopedia of Pharmaceutical Technology, 2328-2337.
  3. Fu X., et al. “Effects of formulation factor on encapsulation efficiency and release behavior in- vitro of huperzine A-PLGA microspheres”. Journal of Microencapsulation 22 (2005): 705-714.
  4. Chien YW., et al. “Concepts and System Design for Rate-controlled Drug Delivery” Chapter 1”. Novel Drug Delivery System 2 (19920): 1-42.
  5. Rouge N., et al. “Drug absorption sites in the gastrointestinal tract and Dosage forms for site specific delivery” (1996).
  6. Ghalop SB., et al. “Hollow microsphere a Review”. International Journal of Pharmaceutical Science Review and Research 1 (2010): 10-15.
  7. Kataria S., et al. “Microsphere A Review”. International Journal of Research in Pharmacy and Chemistry 1(2011): 1184-1198.
  8. Mathew Sam T., et al. “NSAIDs as microspheres”. The Internet Journal of Pharmacology1 (2008): 67-73.
  9. Li SP., et al. “Recent Advances in Microencapsulation Technology and Equipment”. Drug Development and Industrial Pharmacy 14 (1988): 353-376.
  10. Vyas PS., et al. “Drug delivery system”. 2 (2012): 397-399.
  11. Sipai Altaf Bhai., et al. “Mucoadhesive Microsphere An overview”. American Journal of Pharmtech Research1 (2012): 237-258.
  12. Nalini M., et al. “Con-A conjugated mucoadhesive microspheres for the colonic delivery of diloxanide furoate”. International Journal of Pharmaceutics 359 (2008): 182-189.
  13. Alexander K., et al. “Polymeric carriers for oral uptake of micro particulates”. Advanced Drug Delivery Reviews 34 (1998): 155-170.
  14. I Genta P., et al. “Enzyme loaded biodegradable microspheres in vitro ex vivo evaluation”. Journal of Controlled Release 77 (2001): 287-295.
  15. P Dutta J., et al. “Floating Microsphere: Recent Trends in the Development of Gastroretentive Floating Drug Delivery System”. International Journal of Pharmaceutical Science and Nanotechnology1 (2011): 1293-1306.
  16. Sipai Altaf Bhai., et al. “Mucoadhesive Microsphere An overview”. American Journal of Pharmtech Research1 (2012): 237-258.
  17. Guojun Liu., et al. “Preparation of magnetic microsphere from waterin- oil emulsion stabilized by block copolymer dispersant”. Biomacromolecules 6 (2005): 1280-1288.
  18. Dr Fishers., et al. “Microsphere Selection Bangs laboratories inc, Tech”. Notes 201A 1-4.
  19. Lachman L., et al. “The Theory and Practice of Industrial Pharmacy”. Philadelphia, Lea and Febiger, (1987).
  20. Kunchu K., et al. “Albumin microspheres: An Unique System as drug Delivery Carriers for non steroidal anti-inflammatory drugs (NSAIDS)”. International Journal of Pharmaceutical Sciences Review and Research 5(2010): 10-17.
  21. Khar RK. “Targeted and Controlled Drug Delivery – Novel Carrier System”. New Delhi: CBS Publication and Distributors (2002).
  22. Mathew Sam T., et al. “NSAIDs as microspheres”. The Internet Journal of Pharmacology1 (2008): 67-73.
  23. Dixit M., et al. “Spray Drying: A crystallization Technique: A review”. International Journal of Drug Formulation and Research 1 (2010): 1-29.
  24. Madhav NVS. “Review on microparticulate drug delivery system” . International Journal of Pharm Tech Research 3 (2011): 1242-1254.
  25. Mathew Sam T., et al. “NSAIDs as microspheres”. The Internet Journal of Pharmacology1 (2008): 67-73.
  26. Kunchu K., et al. “Albumin microspheres: An Unique System as drug Delivery Carriers for non steroidal anti-inflammatory drugs (NSAIDS)”. International Journal of Pharmaceutical Sciences Review and Research 5(2010): 10-17.
  27. Srivastava P. “Application and advancement of microspheres as controlled drug delivery system”. International Journal of Pharmacy and Life Sciences 4 (2013): 2583-2594.
  28. Jagtap YM., et al. “Effect of various polymers concentrations on physicochemical properties of floating microspheres”. Indian Journal of Pharmaceutical Sciences 74 (2012): 512-520.
  29. Rajkumar K, et al. “Floating Microspheres: A Novel Approach in drug delivery”. Journal of Drug Delivery Research 1 (2012): 1-20.
  30. Pandya N., et al. “Preparation and in vitro characterization of porous carrier based glipizide floating microspheres for gastric delivery”. Journal of Young Pharmacists 3 (2011): 97-104.
  31. Soni LM., et al. “Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation”. International Journal of Drug Delivery 2 (2010): 64-68.
  32. Dey S., et al. “Formulation and optimization of sustained release stavudine microspheres using response surface methodology”. International Scholarly Research Notices Pharmaceutics (2011).
  33. Gaba P., et al. “Galactomannan gum coated mucoadhesive microspheres of glipizide for treatment of type 2 diabetes mellitus: In vitro and in vivo evaluation”. The Saudi Pharmaceutical Journal3(2011):143-152.
  34. Gangadharappa HV., et al. “Development, in vitro and in vivo Evaluation of Novel Floating Hollow Microspheres of Rosiglitazone Maleate”. Der Pharmacia Lettre 3 (2011): 299-316.
  35. Garg A., et al. “Mucoadhesive microspheres: A short review”. Asian Journal of Pharmaceutical and Clinical Research 5 (2012): 24-27.
  36. Marwa H., et al. “Development and Characterization of Controlled Release Ketoprofen Microspheres”. Journal of Applied Pharmaceutical Science 2 (2012): 60-67.
  37. Reddy PC., et al. “A review on bioadhesive buccal drug delivery systems: current status of formulation and evaluation methods”. DARU, Journal of Pharmaceutical Sciences 19 (2011): 385-403.
  38. Funden Berg H., et al. “In: Basic and clinical immunology”. Lange Medical, Los Altosca 2 (1978).
  39. Kumari Pushpa., et al. “Formulation and evaluation of tolnaftate microsponges loaded gels for treatment of dermatophytosis”. European Journal of Pharmaceutical and Medical Research (2017): 326-335.
  40. Ganesan P., et al. “Review on Microsphere”. American Journal of Drug Discovery and Development 4 (2014): 153-179.
  41. Das MK., et al. “Sorbitan ester niosomes for topical delivery of rofecoxib”. Indian Journal of Experimental Biology 49 (2011): 438-445.
  42. Paolo Yammine., et al. “Preparation and Characterization of Antifungal Drug-loaded Poly(dl-lactideco-caprolactone) and Poly(l-lactide-co-caprolactone-co-glycolide)”. International Journal of Novel Drug Delivery Technology4 (2011).
  43. Neeraja P., et al. “Formulation and evaluation of gel loaded with microspheres of apremilast for transdermal delivery system”. Asian journal of Pharmaceutical and Clinical Research2 (2019): 411-417.
  44. Banasmita Kalita., et al. “Formulation and evaluation of metronidazole microspheres-loaded bioadhesive vaginal gel”. Asian journal of Pharmaceutical and Clinical Research3 (2017): 418-424.
  45. Ranu Biswas., et al. “Development and characterization of novel herbal formulation (polymeric microspheres) of Syzygium cumini seed extract”. International Journal of Applied Pharmaceutics5 (2018): 226-234.
  46. Azmat Ali Khana., et al. “Antifungal efficacy of amphotericin B encapsulatedfibrin microsphere for treating Cryptococcusneoformans infection in Swiss albino mice”. 593 (2016): 1-7.
  47. Paolo Yammine., et al. “Study of different processing parameters for polylactic acid microspheres formulations”. International Journal of Pharmaceutical Sciences and Research10 (2014): 4176-4181.
  48. Tarun Virmani., et al. “In vitro Evaluation and Characterization Methods of Antifungal Agent as Microspheres”. International Journal of Pharmacy and Pharmaceutical Sciences 17 (2018): 90-96.

Citation

Citation: Shashi Kiran Misra., et al. “Microspheres: The Efficient Controlled Drug Delivery Carriers". Acta Scientific Pharmaceutical Sciences 6.8 (2022): 33-44.

Copyright

Copyright: © 2022 Shashi Kiran Misra., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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