Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 6 Issue 8

Formulation and Evaluation of Clarithromycin Enteric Coated Microcapsules Using 22 - Full Factorial Designs

Kabita Banik1*, S Namratha2 and Twila Pushpa3

1Assistant Professor, Department of Pharmaceutics, Bharat Institute of Technology, Mangalpally, Hyderabad, Telangana, India
2Assistant Professor, Department of Pharmaceutical Analysis, Bharat Institute of Technology, Mangalpally, Hyderabad, Telangana, India
3Assistant Professor, Department of Pharmacy Practice, Bharat Institute of Technology, Mangalpally, Hyderabad, Telangana, India

*Corresponding Author: Kabita Banik, Assistant Professor, Department of Pharmaceutics, Bharat Institute of Technology, Mangalpally, Hyderabad, Telangana, India.

Received: May 30, 2022; Published: July 03, 2022

Abstract

The purpose of the research was to develop and evaluate Clarithromycin loaded, Cellulose acetate phthalate (CAP) enteric coated, controlled release microcapsules where talc is used as an anti aggrading agent. Clarithromycin degrades rapidly at normal gastric pH (1.0-2.0) and remains stable at intestinal pH at 7.4-10 and shows rapid first-pass hepatic metabolism. In order to improve the bioavailability and reduce the gastric degradation, enteric coating microencapsulation was prepared. Clarithromycin microcapsules were formulated by solvent evaporation technique while using 22 factorial designs. A 22 full factorial designs was used to derive a statistical equation, ANOVA analysis, contour plots, and 3D response surface plots. Different polymer and anti aggregating agent ratios of CAP and talc were used to formulate five formulations (F1 to F5) of microcapsules. The relationship between dependent variables (Percentage drug release, drug entrapment efficiency, angle of repose) and independent variables (CAP and Talc) has been established by regression analysis and ANOVA.

The optimized formulations F2 exhibited high drug entrapment efficiency of 94.90 ± 0.02%, Angle of repose of % drug release of 71.51 ± 0.04% at 10 hrs. Microcapsules showed drug release by diffusion in the hydrated matrix and polymer relaxation as a controlled release mechanism.

Keywords: Clarithromycin; Enteric Coated Microencapsulation; Solvent Evaporation Technique; Cellulose Acetate Phthalate (CAP); Factorial Design

References

  1. Malhotra-Kumar S., et al. "Effect of azithromycin and clarithromycin therapy on pharyngeal carriage of macrolide-resistant streptococci in healthy volunteers: A randomised, double-blind, placebo-controlled study". Lancet9560(2007): 482-490.
  2. Pharmaceutical Development and Technology4(2001): 607-6149.
  3. CJ Malm., et al. "Preparation of Phthalic Acid Esters of Cellulose”. Journal of Industrial and Engineering Chemistry (2005): 658.
  4. Iranian Polymer Journal12 (2005): 1058-1065.
  5. Spitael J., et al. "Dissolution rate of cellulose acetate phthalate and Brönsted catalysis law”. Pharmazeutische Industrie 42 (1980): 846-849.
  6. Dubey R., et al. "Microencapsulation Technology and Applications”. Defence Science Journal 1 (2009): 82-95.
  7. Ardenia A and Gupta AK. “Development and optimization of gastroretentive mucoadhesive microspheres using 33 factorial design”. International Journal of Pharmaceutical Sciences and Research 5 (2016): 2020-2030.
  8. Abraham S., et al. "Preparation, evaluation and in-vitro characterization of biopolymer derived hybrid microcapsules for extended release of cefaclor”. International Journal of Chemical and Pharmaceutical Sciences 2 (2014): 145-155.
  9. Takenaka H., et al. "Preparation of enteric-coated microcapsules for tableting by spray-drying technique and in vitro simulation of drug release from the tablet in GI tract”. Journal of Pharmaceutical Sciences 69 (1980): 1388-1392.
  10. Paul B., et al. "Formulation and in-vitro evaluation of metronidazole loaded HPMC K15M mucoadhesive microcapsules for H. pylori infection using 32- full factorial designs”. International Journal of Pharmaceutical Sciences and Research 2(2019): 555-567.

Citation

Citation: Kabita Banik., et al. “Formulation and Evaluation of Clarithromycin Enteric Coated Microcapsules Using 22 - Full Factorial Designs". Acta Scientific Pharmaceutical Sciences 6.8 (2022): 42-53.

Copyright

Copyright: © 2022 Kabita Banik., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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