Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 6 Issue 1

Formulation and Evaluation of Floating Drug Delivery System for Oxcarbazepine

Gunasekar Manoharan1*, Balaji Nagarajan1 and Bhargava Gottam2

1New Jersey Bioscience Centre, New Jersey, USA
2Harrisburg University of Science and Technology, Pennsylvania, USA

*Corresponding Author: Gunasekar Manoharan, New Jersey Bioscience Centre, New Jersey, USA.

Received: December 10, 2021; Published: December 27, 2021

Abstract

Sustained release tablets of oxcarbazepine that float, erode and diffuse were prepared using various hydrophilic polymers. The buoyancy of the tablets was achieved by incorporation of the gas-generating agent sodium bicarbonate. The effect of various parameters on buoyancy and release profile was investigated. The tablets became buoyant within minutes and floated for more than 12 hours in vitro with good integrity and released more than 90% of the drug. The tablets exhibited prolonged floating properties due to low density polymers and formation of CO2 by a gas generating material. A zero-order drug release involving swelling and erosion of the system was observed. This study shows that tablet composition and mechanical strength have the greatest influence on the floating properties and sustained drug release. The system was shown to have an excellent floating ability and sustained release characteristics in vitro, irrespective of pH. The floating dosage form was found to be a feasible approach in delivering oxcarbazepine to the upper GIT to maximize drug absorption.

Keywords: Oxcarbazepine; Floating Tablets; HPMC K 4M; HPMC K 15M

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Citation

Citation: Gunasekar Manoharan., et al. “Formulation and Evaluation of Floating Drug Delivery System for Oxcarbazepine". Acta Scientific Pharmaceutical Sciences 6.1 (2022): 145-151.

Copyright

Copyright: © 2022 Gunasekar Manoharan., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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