Formulation and Evaluation of Cyclodextrin Loaded Rivaroxaban Fast Dissolving Tablets
Trinadha Rao M*, Raju M, Swetha K, Jyosna J, Bhargav G, CVS Phanindra, A Swathi Annapurna and Y Srinivasa Rao
Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, India
*Corresponding Author: Trinadha Rao M, Associate Professor, Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, India.
October 29, 2021; Published: December 20, 2021
The present investigation was undertaken in formulating fast dissolving tablets of the anticoagulant drug Rivaroxaban. Rivaroxaban is an orally bio available oxozolidine derivative and direct inhibitor of coagulation factor Xa with anti coagulant activity upon oral administration rivaroxaban selectivly bind to both free factor Xa bound in the prothrombinase complex. The main objective is to enhance the quick on set of action, convenience and compliance by the elderly and pediatric patients without the problem of swallowing and using water. Rivaroxaban belongs to BCS Class-II with low solubility and high permeability. The solubility of Rivaroxaban is enhanced by complexing with cyclodextrin. The inclusion complexes of Rivaroxaban were prepared by various techniques using HP β cyclodextrin in various ratios (1:1 and 1:2). Solubility study of Rivaroxaban was performed in which highest was observed for 1:2 ratio. The selected inclusion complexes were then utilized for the preparation of tablets by direct compression. Five formulae were prepared and evaluated for in vitro dissolution characteristics, in vitro disintegration time, wetting time, and their physico-mechanical properties. The promising tablets (F5) showed greatest drug dissolution (more than 85% within 30 min), satisfactory in vitro disintegration time (24 sec) and physico-mechanical properties that are suitable for fast dissolving tablets. By complexation taste masking also improved.
Keywords: Rivaroxaban; Fast Dissolving Tablets; Wetting time, Lactose; HP Cyclodextrin; Sodium Starch Glycollate; Cross Carmellose Sodium; Microcrystalline Cellulose
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