Trinadha Rao M*, Raju M, Swetha K, Jyosna J, Bhargav G, CVS Phanindra, A Swathi Annapurna and Y Srinivasa Rao

Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, India

*Corresponding Author: Trinadha Rao M, Associate Professor, Vignan Institute of Pharmaceutical Technology, Duvvada, Visakhapatnam, India.

Received: October 29, 2021; Published: December 20, 2021

Abstract

The present investigation was undertaken in formulating fast dissolving tablets of the anticoagulant drug Rivaroxaban. Rivaroxaban is an orally bio available oxozolidine derivative and direct inhibitor of coagulation factor Xa with anti coagulant activity upon oral administration rivaroxaban selectivly bind to both free factor Xa bound in the prothrombinase complex. The main objective is to enhance the quick on set of action, convenience and compliance by the elderly and pediatric patients without the problem of swallowing and using water. Rivaroxaban belongs to BCS Class-II with low solubility and high permeability. The solubility of Rivaroxaban is enhanced by complexing with cyclodextrin. The inclusion complexes of Rivaroxaban were prepared by various techniques using HP β cyclodextrin in various ratios (1:1 and 1:2). Solubility study of Rivaroxaban was performed in which highest was observed for 1:2 ratio. The selected inclusion complexes were then utilized for the preparation of tablets by direct compression. Five formulae were prepared and evaluated for in vitro dissolution characteristics, in vitro disintegration time, wetting time, and their physico-mechanical properties. The promising tablets (F5) showed greatest drug dissolution (more than 85% within 30 min), satisfactory in vitro disintegration time (24 sec) and physico-mechanical properties that are suitable for fast dissolving tablets. By complexation taste masking also improved.

Keywords: Rivaroxaban; Fast Dissolving Tablets; Wetting time, Lactose; HP Cyclodextrin; Sodium Starch Glycollate; Cross Carmellose Sodium; Microcrystalline Cellulose

References

1. Sachin G., et al. “Formulation and evaluation of fast dissolving tablets of etoricoxib”. world journal pharmacy and pharmaceutical science 4 (2015): 1357-1376.
2. Prameela Rani A., et al. “Formulation and Evaluation of Fast Disintegrating Tablets of Anti-inflammatory Drug Flurbiprofen”. Scholars Research Journal 10 (2018): 68-77.
3. Swati S., et al. “Formulation and Evaluation of Glipizide Fast Dissolving Tablets”. Journal of Pharmaceutical Sciences and Research 12 (2020): 609-611.
4. https://www.statpearls.com/ArticleLibrary/viewarticle/86483
5. Madhuri TH and Ravi DH. “Formulation and Evaluation of Fast Dissolving Tablet of Lamotrigine”. International Journal of Pharmaceutical Sciences and Drug Research 7 (2018): 50-57.
6. Pavan KR., et al. “Fast Dissolving Tablets of Pioglitazone Hydrochloride by Use of Various Super disintegrants”. International Journal of Advanced Research in Biological Sciences 3 (2013): 74-79.
7. Rao MT., et al. “Formulation and characterization of indomethacin cyclodextrin loaded mouth dissolving films”. International Journal of Current Advanced Research 8 (2018): 15110-15117.
8. Hannan AP., et al. “Oral dispersible system: A new approach in drug delivery system”. Indian Journal of Pharmaceutical Sciences 78 (2016): 2-7.
9. Reddy HL., et al. “Fast dissolving drug delivery systems: A Review of the Literature”. Indian Journal of Pharmaceutical Sciences 64 (2002): 331-336.
10. Rao MT., et al. “Development and validation of RP-HPLC method for the determination of itraconazole in bulk and capsule dosage form”. International Journal of Pharmaceutical Sciences Review and Research 31 (2015): 221-225.
11. Wyawahare NS., et al. “Fast dispersing tablets of diclofenac sodium with natural superdisintegrants”. International Journal of Current Research and Review 4 (2010): 20-29.
12. Chilate VC., et al. “To Mask the Bitter Taste of Rizatriptan Benzoate and Develop Water Dispersible Tablets”. International Journal of Current Research and Review 9 (2017): 39-48.
13. Korsmeyer RW., et al. “Mechanism of solute release from porous hydrophilic polymers”. International Journal of Pharmaceutical 15 (1983): 35-39.
14. Dasari N and Maruvajala V. “Preparation and evaluation of fast dissolving tablets of pitavastatin by 32 full factorial design”. International Journal of Applied Pharmaceutics 12 (2020): 108-114.
15. Costa P., et al. “Modelling and comparison of dissolution profiles”. European Journal of Pharmaceutical Sciences 13 (2001): 123-133.
16. SG Gattani and RS Moon. “Formulation and evaluation of fast dissolving tablet containing vilazodone nanocrystals for solubility and dissolution enhancement using soluplus: in vitro-in vivo study”. Journal of Applied Pharmaceutical Science 8 (2018): 045-054.
17. Vishal Dhiman., et al. “Formulation and in-vitro evaluation of fast dissolving tablets of telmisartan”. International Journal of Pharmacy and Life Sciences 3 (2012): 2159-2164.
18. Bhavani BK., et al. “Preparation and evaluation of inclusion complexes of Felodipine”. Journal of Global Trends in Pharmaceutical sciences 3 (2012): 576-584.

Citation

Citation: Trinadha Rao M., et al. “Formulation and Evaluation of Cyclodextrin Loaded Rivaroxaban Fast Dissolving Tablets". Acta Scientific Pharmaceutical Sciences 6.1 (2022): 106-112.

Copyright

Copyright: © 2022 Trinadha Rao M., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.