Poonam Singh, Vaibhav Walia and Prabhakar Kumar Verma*

Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India

*Corresponding Author: Prabhakar Kumar Verma, Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana, India.

Received: November 01, 2021; Published: December 16, 2021

Abstract

Ion channel playa essential role in glucose induced insulin secretion. Insulin secretion by β cells of pancreas that response to an increase the blood glucose levels in body. It plays an important role to maintain homeostasis of glucose. Glucose stimulated insulin secretion (GSIS) in β cells of pancreas have explored. Glucose enters in cell membrane then later in metabolic pathway. In this manner the ratio of ATP/ADP (adenosine triphosphate/adenosine di-phosphate) increase cause to closing of ATP-sensitive potassium channel (KATP) channels leading to depolarization of membrane. Depolarization cause to opening of voltage gated sodium channels (Nav) later voltage dependent calcium channels (Cav). Increasing of calcium in intra-cellular membrane cause the insulin exocytosis from insulin containing vesicles. Then electrical activity of β cell of pancreas plays an important role in the GSIS. Furthermore, incretins, some neurotransmitters hormones and growth factors, can modulate the GSIS. In this review we discuss on ion channels and types of ion channel, role of KATP, Nav, Cav and Cl channels in insulin secretion, expression of ion channel, alteration of ion channel in diabetes mellitus disorder, ion channel as a drug target in diabetes mellitus.

Keywords: Ion Channel; Diabetes Mellitus; Insulin Secretion; Pancreatic Β Cell

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Citation

Citation: Prabhakar Kumar Verma., et al. “Role of Ion Channel Modulator in Diabetes Mellitus". Acta Scientific Pharmaceutical Sciences 6.1 (2022): 76-84.

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Copyright: © 2022 Prabhakar Kumar Verma., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.