Manan Patel^1,2*, Rigved Nagarkar¹, Srushti Sodha¹, Harshil M Parikh³ and Sowmya Kulal⁴

¹University of the Sciences in Philadelphia, PA, USA
²Biolink Life Sciences, NC, USA
³Teva Pharmaceutical Salt Lake City, USA
⁴Alcami, NC, USA

*Corresponding Author: Manan Patel, Department of Pharmaceutical Sciences, University of the Sciences in Philadelphia, USA.

Received: November 01, 2021; Published: December 09, 2021

Abstract

Although solid-oral dosage forms have the market and patient tolerance monopoly, the transdermal route is emerging as an attractive, non-invasive approach to deliver drugs topically and systemically. The skin is designed to prevent entry of foreign molecules, thereby presenting hurdles to drug permeation. Different penetration enhancers help circumvent this problem as they act at different sites of action and have different mechanisms of action. These include altering metabolic activity within the skin exerting an influence on the thermodynamic activity of the drug in its vehicle, changing metabolism rate inside the epidermis and/or influencing the thermodynamics action of the drug in its carrier. A variety of cutaneous permeation enhancers were studied and evaluated for skin permeation enhancement. The aim of this review article is to highlight various FDA approved pharmaceutical permeation enhancers and understand their mechanisms of action. A deeper dive into traditional and modern permeability enhancement techniques and understand their mechanisms which might help extrapolate the relevance of these technique/excipients for case-specific permeation enhancement.

Keywords: Skin; Topical; Delivery; Cutaneous; Penetration; Iontophoresis; Electroporation; Sonophoresis; Microfabrication Microneedles Technology; Needleless Injection; Thermophoresis; Magnetophoresis; Ceramide Analogs; Azone Analogs; Menthol Analogs; Transkarbams; Laser Radiations

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Citation

Citation: Manan Patel., et al. “Overview of Modern and Traditional Techniques of Permeation Enhancement for Topical Drug Deliver". Acta Scientific Pharmaceutical Sciences 6.1 (2022): 44-54.

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Copyright: © 2022 Manan Patel., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.