Overview of Modern and Traditional Techniques of Permeation Enhancement for Topical Drug Deliver
Manan Patel1,2*, Rigved Nagarkar1, Srushti Sodha1, Harshil M Parikh3 and Sowmya Kulal4
1University of the Sciences in Philadelphia, PA, USA
2Biolink Life Sciences, NC, USA
3Teva Pharmaceutical Salt Lake City, USA
4Alcami, NC, USA
*Corresponding Author: Manan Patel, Department of Pharmaceutical Sciences, University of the Sciences in Philadelphia, USA.
November 01, 2021; Published: December 09, 2021
Although solid-oral dosage forms have the market and patient tolerance monopoly, the transdermal route is emerging as an attractive, non-invasive approach to deliver drugs topically and systemically. The skin is designed to prevent entry of foreign molecules, thereby presenting hurdles to drug permeation. Different penetration enhancers help circumvent this problem as they act at different sites of action and have different mechanisms of action. These include altering metabolic activity within the skin exerting an influence on the thermodynamic activity of the drug in its vehicle, changing metabolism rate inside the epidermis and/or influencing the thermodynamics action of the drug in its carrier. A variety of cutaneous permeation enhancers were studied and evaluated for skin permeation enhancement. The aim of this review article is to highlight various FDA approved pharmaceutical permeation enhancers and understand their mechanisms of action. A deeper dive into traditional and modern permeability enhancement techniques and understand their mechanisms which might help extrapolate the relevance of these technique/excipients for case-specific permeation enhancement.
Keywords: Skin; Topical; Delivery; Cutaneous; Penetration; Iontophoresis; Electroporation; Sonophoresis; Microfabrication Microneedles Technology; Needleless Injection; Thermophoresis; Magnetophoresis; Ceramide Analogs; Azone Analogs; Menthol Analogs; Transkarbams; Laser Radiations
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