Arunadevi S Birajdar¹* and SN Meyyanathan²

¹HOD, Department of Pharmaceutical Analysis, K. T. Patil College of Pharmacy, Osmanabad, India
²HOD, Department of Pharmaceutical Analysis, JSS College of Pharmacy, Ooty, Tamilnadu, India

*Corresponding Author: Arunadevi S Birajdar, HOD, Department of Pharmaceutical Analysis, K. T. Patil College of Pharmacy, Osmanabad, India.

Received: October 25, 2021; Published: November 30, 2021

Abstract

Development of UV spectrophotometric methods, Q- analysis method and first derivative method have been carried out and validated for estimation of Rabeprazole and Diclofenac sodium Capsules and Rabeprazole and Domperidone capsules which are used as proton pump inhibitor and antiemetic for the short-term treatment of nausea and vomiting, similarly Rabeprazole and Diclofenac sodium also used as relief of pain and inflammation in ulceric conditions in capsule dosage form. These Methods has been carried out by using 0.1N NaOH solution as solvent which is very economical as well easily available. The Q-analysis was based on the measurement of UV light absorbance of Rabeprazole, Domperidone at wavelength 291.2 nm, 240 nm and Rabeprazole, Diclofenac sodium at wavelength 275.6 nm, 245.2 nm respectively in freshly prepared dilute 0.1N NaoH solution. First derivative based on measurement of ratio of difference in wavelength and concentration dy/dx at wavelength of Rabeprazole, Domperidone at 265.1 nm, 244.6 nm and Rabeprazole, Diclofenac sodium at 275.2 nm, 252.2 nm respectively. The standard solutions obeyed Beer’s law at the concentration range of 2 - 10 µg/ml for Rabeprazole, 3 - 18 µg/ml for Domperidone and 2 - 10 µg/ml Rabeprazole, 10 - 50 µg/ml Diclofenac sodium. The results of analysis and recovery studies had been carried out as per ICH Guidelines and validated which confirmed the accuracy of the proposed methods. These methods can be used for determination of different formulations.

Keywords: Rabeprazole; Domperidone; Diclofenac Sodium; Q-Analysis; First Derivative; UV Spectrophotometer

References

1. The Martindale 35^th, The complete drug reference, published pharmaceutical press, lambeta high street, londan SEI 75M, UK (2006).
2. S Rena., et al. “Effect of pharmaceutical excipients on aqueous stability of rabeprazole sodium”. International Journal of Pharmaceutics 350 (2008): 197-204.
3. NVS Ramakrishna., et al. “High-performance liquid chromatography method for the quantification of rabeprazole in human plasma using solid-phase extraction”. Journal of Chromatography B 816 (2005): 209-214.
4. SS Sabnis., et al. “Spectrophotometric simultaneous determination of Rabeprazole Sodium and Itopride Hydrochloride in capsule dosage form”. Spectrochimica Acta Part A 69 (2008): 849-852.
5. M Miura., et al. “Determination of rabeprazole enantiomers and their metabolites by high-performance liquid chromatography with solid-phase extraction”. Journal of Pharmaceutical and Biomedical Analysis 41 (2006): 565-570.
6. CV Garcia., et al. “Structural elucidation of rabeprazole sodium photodegradation products”. Journal of Pharmaceutical and Biomedical Analysis 46 (2008): 88-93.
7. A El-Gindy., et al. “Spectrophotometric and chromatographic determination of rabeprazole in presence of its degradation products”. Journal of Pharmaceutical and Biomedical Analysis 31 (2003): 229-242.
8. AM Pimenta., et al. “Simultaneous potentiometric and fluorimetric determination of diclofenac in a sequential injection analysis system”. Analytica Chimica Acta 470 (2002): 185-194.
9. Maria Kobylin´ska and Kamila Kobylin´ska. “High-performance liquid chromatographic analysis for the determination of domperidone in human plasma”. Journal of Chromatography B 744 (2000): 207.
10. Maurizio Cignitti., et al. “UV spectroscopic study and conformational analysis of Domperidone”. Journal of Molecular Structure 350 (1995): 43.
11. ICH, Q2A validation of analytical procedure: Methodology International Conference on Harmonization, Geneva, October (1994).

Citation

Citation: Arunadevi S Birajdar and SN Meyyanathan. “Development of Two UV Spectrophotometric Methods for Estimation of Rabeprazole with Diclofenac Sodium Capsules and Rabeprazole with Domperidone Capsules". Acta Scientific Pharmaceutical Sciences 5.12 (2021): 71-76.

Copyright

Copyright: © 2021 Arunadevi S Birajdar and SN Meyyanathan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.