Arunadevi S Birajdar1* and SN Meyyanathan2
1HOD, Department of Pharmaceutical Analysis, K. T. Patil College of Pharmacy, Osmanabad, India
2HOD, Department of Pharmaceutical Analysis, JSS College of Pharmacy, Ooty, Tamilnadu, India
*Corresponding Author: Arunadevi S Birajdar, HOD, Department of Pharmaceutical Analysis, K. T. Patil College of Pharmacy, Osmanabad, India.
Received: October 25, 2021; Published: November 30, 2021
Development of UV spectrophotometric methods, Q- analysis method and first derivative method have been carried out and validated for estimation of Rabeprazole and Diclofenac sodium Capsules and Rabeprazole and Domperidone capsules which are used as proton pump inhibitor and antiemetic for the short-term treatment of nausea and vomiting, similarly Rabeprazole and Diclofenac sodium also used as relief of pain and inflammation in ulceric conditions in capsule dosage form. These Methods has been carried out by using 0.1N NaOH solution as solvent which is very economical as well easily available. The Q-analysis was based on the measurement of UV light absorbance of Rabeprazole, Domperidone at wavelength 291.2 nm, 240 nm and Rabeprazole, Diclofenac sodium at wavelength 275.6 nm, 245.2 nm respectively in freshly prepared dilute 0.1N NaoH solution. First derivative based on measurement of ratio of difference in wavelength and concentration dy/dx at wavelength of Rabeprazole, Domperidone at 265.1 nm, 244.6 nm and Rabeprazole, Diclofenac sodium at 275.2 nm, 252.2 nm respectively. The standard solutions obeyed Beer’s law at the concentration range of 2 - 10 µg/ml for Rabeprazole, 3 - 18 µg/ml for Domperidone and 2 - 10 µg/ml Rabeprazole, 10 - 50 µg/ml Diclofenac sodium. The results of analysis and recovery studies had been carried out as per ICH Guidelines and validated which confirmed the accuracy of the proposed methods. These methods can be used for determination of different formulations.
Keywords: Rabeprazole; Domperidone; Diclofenac Sodium; Q-Analysis; First Derivative; UV Spectrophotometer
Citation: Arunadevi S Birajdar and SN Meyyanathan. “Development of Two UV Spectrophotometric Methods for Estimation of Rabeprazole with Diclofenac Sodium Capsules and Rabeprazole with Domperidone Capsules". Acta Scientific Pharmaceutical Sciences 5.12 (2021): 71-76.
Copyright: © 2021 Arunadevi S Birajdar and SN Meyyanathan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.