Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Short Communication Volume 5 Issue 12

The Diverse Cytotoxicity Evaluation of Lactobacillus Discovered from Sheep Milk

Abhinandan Patil1*, Vijay Mali2 and Atharv Mali1

1School of Pharmaceutical Science, Sanjay Ghodawat University, Kolhapur, India
2NICE Advanced Neonatal Care Centre and Children Clinic, Kolhapur, India

*Corresponding Author: Abhinandan Patil, School of Pharmaceutical Sciences, Sanjay Ghodawat University, Kolhapur, India

Received: November 22, 2021; Published: November 30, 2021


LAB: Lactobacillus; Lp: Lactobacillus plantarum; Lr: Lactobacillus rhamnosus; La: Lactobacillus acidophilus

The pharmacology research, for the evaluation of the toxicity, is become vital in regards to the neutraceuticals products development [1,7-10]. The cytotoxicity studies of the nutraceutical products, especially the lactobacillus (LAB) formulation are gaining importance due to its industrial application [11, 12]. The interaction of the probiotics cells with the living host cells may rarely precipitate toxicity [1-3,13, 14,17,18]. The interaction of the LAB in pathophysiological conditions such as cancer is gaining importance as an alternative source of functional food [14-16].

Keywords: Lactobacillus; probiotics; assay; MTT


  1. Abhinandan Patil and Pawar S. “Health benefits of Probiotics by Antioxidant Activity: A review”. Pharma Times9 (2018): 1-3.
  2. Abhinandan Patil., et al. “Granules of unistrain lactobacillus as nutraceutical antioxidant agent” 9.4 (2017): 1594-1599.
  3. Disouza J and Patil A. “Antioxidant study and phenolic content of Caralluma fimbriata herb”. World Journal of Pharmaceutical Research7 (2014): 565-575.
  4. Hamada S., et al. “Evaluation of the rodent micronucleus assay by a 28‐day treatment protocol: Summary of the 13th Collaborative Study by the Collaborative Study Group for the Micronucleus Test (CSGMT)/Environmental Mutagen Society of Japan (JEMS)-Mammalian Mutagenicity Study Group (MMS)”. Environmental and Molecular Mutagenesis2 (2001): 93-110.
  5. Patil A and Disouza J. “Genomic-Based Restriction Enzyme Selection for Specific Detection of Lactobacillus rhamnosus and Lactobacillus plantarum strain by 16S rDNA PCR-RFLP”. International Journal of Innovative Science, Engineering and Technology1 (2020): 91-99.
  6. Patil A., et al. “Shelf-life stability of encapsulated lactic acid bacteria isolated from Sheep milk thrived in different milk as natural media”. Small Ruminant Research 170 (2019): 19-25.
  7. Patil A., et al. “Evaluation of Lactobacillus plantarum growth in milk of Indian buffalo breeds based on its physico-chemical content”. Buffalo Bulletin2 (2019): 345-352.
  8. Patil A., et al. “Probiotic potential of Lactobacillus plantarum with the cell adhesion properties”. Journal of Global Pharma Technology12 (2018): 1-6.
  9. Patil A., et al. “Complete Genome Sequence of Lactobacillus plantarum Strain JDARSH, Isolated from Sheep Milk”. Microbiology Resource Announcements2 (2020).
  10. Patil A., et al. “Banana fibers camouflaging as a gut worm in a 6-month-old infant”. Iberoamerican Journal of Medicine 3 (2020): 245-247.
  11. Patil AR. “Lactobacillus rhamnosus ARJD as a Functional Food with Potential Antioxidant and Antibacterial Abilities”. Acta Scientific Pharmaceutical Sciences 3 (2019): 63-70.
  12. Patil AR. “Use of Probiotics as a Functional Food against Cancer”. Acta Scientific Pharmaceutical Sciences8 (2019): 103-105.
  13. Patil AR. “The role of the food and fertilizers in antimicrobial resistance in human and its preventive measures”. International Journal of Innovative Science, Engineering and Technology1 (2020): 31-37.
  14. Patil AR. “The origin of novel coronavirus: COVID-19”. International Journal of Innovative Science, Engineering and Technology1 (2020): 18-23.
  15. Patil AR., et al. “Nanotechnology based upgradation in tuberculosis diagnosis and treatment” (2020): 395-414.
  16. Patil AR and Disouza J. “Isolation and characterisation of Lactobacillus species from sheep milk”. International Journal of Innovative Science Engineering and Technology1 (2020): 9-17.
  17. Patil AR and Patil P. “The Insight of Body’s Immune System, Inflammation and Damages in Wound Healing- The review”. International Journal for Research in Applied Science and Engineering Technology8 (2021): 2777-2780.
  18. Patil AR., et al.Lactobacillus Model Moiety a New Era Dosage Form as Nutraceuticals and Therapeutic Mediator”. In Biotechnology and Bio forensics Springer, Singapore (2015): 11-21.


Citation: Abhinandan Patil., et al. “The Diverse Cytotoxicity Evaluation of Lactobacillus Discovered from Sheep Milk". Acta Scientific Pharmaceutical Sciences 5.12 (2021): 69-70.


Copyright: © 2021 Abhinandan Patil., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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