Mohammad Sheibani¹, Yaser Azizi^2,3, Maryam Shayan^4,5, Sadaf Nezamoleslami^4,5, Faezeh Eslami^4,5, Nafise Noroozi^4,5, Hasan Yousefi-Manesh^4,5, Amin Ohadi^4,5, Fereshteh Dalouchi³ and Ahmad Reza Dehpour^4,5*

¹Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
²Physiology Research Center, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
³Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
⁴Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
⁵Experimental Medicine Research Center, Tehran University of Medical Sciences, Tehran, Iran

*Corresponding Author: Ahmad Reza Dehpour, Professor, Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Received: November 03, 2021; Published: November 12, 2021

Abstract

Aim: The production of pro-inflammatory cytokines is one of the underlying reasons for renal ischemia/reperfusion injury (RIRI) that can cause functional disorders in the kidneys. Anti-inflammatory effects of sumatriptan had proved in previous studies. In this study, we aimed to evaluate the protective effect of sumatriptan on renal ischemia/reperfusion injury in rats.

Methods: Both renal arteries of animals in ischemia/reperfusion (I/R) groups clamped by clips for 45 minutes. In pretreatment groups with a single dose of sumatriptan, animals received 0.1, 0.3, 1, and 3 mg/kg doses 30 minutes before I/R. Finally, after 24 hours, renal functional markers (BUN, Creatinine (Cr), Lactate Dehydrogenase (LDH), serum level of inflammatory mediators (TNF-α, IL-1β, and NF-κB), tissue levels of oxidative factors (MDA and MPO), and histopathological changes were evaluated.

Results: Sumatriptan at the doses of 0.1, 0.3, and 1 mg/kg could significantly decrease the inflammatory factors like TNF-α, IL-1β, and NF-κB. The MDA and MPO tissue levels were respectively reduced considerably at (0.3 and 1 mg/kg) and (0.3, 0.1, and 1 mg/kg) doses. All treatment groups showed a significant decrease in serum BUN levels. Sumatriptan treatment also reduced Cr and LDH serum levels at (0.3 mg/kg) and (0.3 and 1 mg/kg) doses, respectively. Treatment of rats with 0.3 mg/kg sumatriptan resulted in remarkable improvement in histopathological damage compared to the I/R group.

Conclusion: Our observation suggests that treatment with low doses of sumatriptan attenuates renal I/R injuries through its anti-inflammatory and anti-oxidative properties.

Keywords: Sumatriptan; Renal Ischemia/Reperfusion; Inflammation; TNF-α; IL-1β; NF-κB; MDA; MPO; Cr; BUN

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Citation

Citation: Ahmad Reza Dehpour., et al. “Protective Effects of Sumatriptan on Renal Ischemia-reperfusion Injury in Male Rats". Acta Scientific Pharmaceutical Sciences 5.12 (2021): 32-41.

Copyright

Copyright: © 2021 Ahmad Reza Dehpour., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.