The Current Landscape of Long-acting Growth Hormone Therapy
University of the Sciences in Philadelphia, Philadelphia, USA
*Corresponding Author: Srushti Sodha, University of the Sciences in Philadelphia, Philadelphia, USA.
August 05, 2021; Published: September 06, 2021
Growth hormone deficiency is a rare disease characterized by short stature, delay in maturation and growth of children due to poor development of the skeletal tissue. The current market for GHD treatment consists of once daily injections as a replacement therapy to growth hormone. The review commences by summarizing the existing FDA approved formulations, with their indications, challenges and dosage regimen. Furthermore, we have reviewed the progress and challenges associated with the long acting formulations undergoing clinical trials currently. Various research projects have implemented alternative routes of delivery such as pulmonary and transdermal, or used nano-systems for controlled release of hGH, thereby reducing the dosing frequency. Our aim is to shed some light on these approaches, while also evaluating their feasibility of traversing from bench to bedside. In this rapidly transient field, we aim to emphasize this review on the research published during or after 2015.
Keywords: Long-acting hGH; PEGylation; Fusion Proteins; Lipidation
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