Acta Scientific Pharmaceutical Sciences (ASPS)(ISSN: 2581-5423)

Research Article Volume 5 Issue 10

Combination of the Leaves of Annona muricata, Launaea taraxacifolia and Tridax procumbens: An Herbal Medicine for the Prevention and Treatment of Hypertension, Atherosclerosis and Cardiovascular Diseases

Betira Mansouratou1, Koukoui Omédine1*, Houngbeme Alban2, Seton Santorin1, Amagbegnon Jean-Baptiste1, Sonounameto Fidèle1 and Sezan Alphonse3

1Laboratory of Animal Physiology, Cellular Signalisation and Pharmacology, University of Sciences Technologies, Engineering and Mathematics, Benin
2Medicinal and Organic Chemistry Laboratory, Faculty of Health Sciences, Benin
3Laboratory of Biomembranes and Cellular Signalisation, University of Abomey-Calavi, Benin

*Corresponding Author: Koukoui Omédine, Laboratory of Animal Physiology, Cellular Signalisation and Pharmacology, University of Sciences Technologies, Engineering and Mathematics, Benin.

Received: August 11, 2021; Published: September 06, 2021

Abstract

  High blood pressure and cardiovascular diseases are the non communicable diseases that cause the most deaths in Africa. They affect the most disadvantaged sections of society who have no other choice but to treat themselves with plants. In the purpose of proposing to the populations an herbal medicine that can help prevent and even treat hypertension and cardiovascular diseases, we have studied the bioactive substances (secondary metabolites, vitamins and minerals) contained in three plants used by traditional healers to treat high blood pressure and cardiovascular diseases. Our results have shown that these plants together contain polyphenols, leucoanthocyanins, anthocyanins, triterpenoids, steroids, reducing compounds, as well as vitamins such as vitamins A, E, C, K1 and minerals like calcium, potassium, iron. These three plants together could constitute a dietary supplement whose regular intake would help prevent or treat high blood pressure, atherosclerosis and cardiovascular diseases.

Keywords: Atherosclerosis; Hypertension; Plants; Prevention; Treatment

References

  1. Organisation Mondiale de la Santé. Rapport de l’Organisation Mondiale de la Santé: Cardiovascular diseases (CVDs). Genève, Suisse: OMS (2017b).
  2. Organisation Mondiale de la Santé. Rapport de l’Organisation Mondiale de la Santé: Réduire la prévalence des maladies non transmissibles au Benin. Genève, Suisse: OMS (2016).
  3. Organisation Mondiale de la Santé. Rapport du groupe d’étude de la classification des lésions d’athérosclérose. Rapport du Directeur Régional. Genève, Suisse OMS (1958).
  4. Montezano AC and Touyz RM. “Molecular mechanisms of hypertension--reactive oxygen species and antioxidants: a basic science update for the clinician”. Canadian Journal of Cardiology3 (2012): 288-295.
  5. Gach O., et al. “Inflammation et Athérosclérose : état de la question en 2004-2005”. Revue médicale de Liège 4 (2005): 235-241.
  6. Beaudeux JL., et al. “Le stress oxydant, composante physiopathologique de l’athérosclérose/Oxidative stress in the atherosclerotic process”. Immuno-analyse and Biologie Spécialisée 21 (2006): 144-150.
  7. Hawa N., et al. “The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease”. Vascular Pharmacology 71 (2015): 40-56.
  8. Rathi V., et al. “Plants used for hair growth promotion: A review”. Pharmacology Review3 (2008): 185-186.
  9. Baskar R., et al. “In vitro antioxydant studies in leaves of Annona species”. Indian Journal of Experimental Biology 45 (2007): 480-485.
  10. Usunobun Usunomena and Okolie N Paulinus. “Phytochemical analysis and Mineral Composition of Annona muricata Leave”. 1.1 (2016): 7-10.
  11. Adinortey MB., et al. “Phytochemical Screening, Proximate and Mineral Composition of Launaea taraxacifolia leaves”. Research Journal of Medicinal Plant 2 (2012): 171-179.
  12. Habila JD., et al. “Total phenolic and antioxidant activity of Tridax procumbens Linn”. African Journal of Pharmacy and Pharmacology 3 (2010): 123-126.
  13. Houghton PJ and Raman A. “Laboratory handbook for the fractionation of natural extracts”. Ed. Chapman and Hall. New York (1998): 208.
  14. Jedlicka A and Klimes J. “Determination of water and fat-soluble Vitamins in different matrices using High-Performance Liquid Chromatography”. Chemical Papers 3 (2005): 202-222.
  15. Ausili A., et al. “Physico chemical characteristics and multivariate analysis of contaminated harbor sediments”. Water Science and Technology6-7 (1998): 131-139.
  16. Akomolafe SF., et al. “Tetracarpidium conophorum (Mull.Arg) Hutch and Dalziel inhibits FeS04 - induced lipid peroxydation in rat’s genitals”. BMC Complementary and Alternative Medicine 15 (2015): 5.
  17. Francesca Santilli., et al. “Oxidative stress in chronic vascular disease: From prediction to prevention”. Vascular Pharmacology 74 (2015): 23-37.
  18. Khurana S., et al. “Oxidative stress and cardiovascular health: therapeutic potential of polyphenols”. Canadian Journal of Physiology and Pharmacology 3 (2013): 198-212.
  19. Khan J., et al. “Dietary Flavonoids: Cardioprotective Potential with Antioxidant Effects and Their Pharmacokinetic, Toxicological and Therapeutic Concerns”. Molecules 13 (2021): 4021.
  20. Sozen E., et al. “Vitamin E: Regulatory role in the cardiovascular system”. IUBMB Life4 (2019): 507-515.
  21. Lewis ED., et al. “Regulatory role of vitamin E in the immune system and inflammation”. IUBMB Life4 (2019): 487-494.
  22. Melissa A Moser and Ock K Chun. “Vitamin C and Heart Health: A Review Based on Findings from Epidemiologic Studies”. International Journal of Molecular Sciences8 (2016): 1328.
  23. Riccioni G., et al. “Carotenoids and vitamins C and E in the prevention of cardiovascular disease”. International Journal for Vitamin and Nutrition Research1 (2012): 15-26.
  24. Somova L I., et al. “Cardiotonic and antidysrhythmic effects of oleanolic and ursolicacids, methylmaslinate and uvaol”. Phytomedicine 11 (2004): 121-129.
  25. Rizwani GH and Shareef H. “The Genus Allium: Potential nutritive and therapeutic source”. Journal of Pharmacy and Nutrition Sciences 1 (2011): 158-165.
  26. Vlasschaert C., et al. “Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials”. Nutrients10 (2020): 2909.
  27. Lees JS., et al. “Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis”. Heart12 (2019): 938-945.
  28. Mark Houston. “The role of magnesium in hypertension and cardiovascular disease”. Journal of Clinical Hypertension (Greenwich) 13.11 (2011) :843-847.
  29. Zhao L., et al. “Quantitative Association Between Serum/Dietary Magnesium and Cardiovascular Disease/Coronary Heart Disease Risk: A Dose-Response Meta-analysis of Prospective Cohort Studies”. Cardiovascular Pharmacology6 (2019): 516-527.
  30. Weaver CM. “Potassium and health”. Advances in Nutrition3 (2013): 368S-377S.
  31. J S Ikonomidis., et al. “Calcium and the heart: an essential partnership”. Canadian Journal of Cardiology7 (1990): 305-316.
  32. Vijay K Chopra and Stefan D Anker. “Beneficial effects of long-term intravenous iron therapy with ferric carboxymaltose in patients with symptomatic heart failure and iron deficiency”. ESC Heart Failure5 (2020): 2007-2011.
  33. Ponikowski P., et al. “Anaemia, iron deficiency and heart failure in 2020: facts and numbers”. European Heart Journal11 (2015): 657-668.

Citation

Citation: Koukoui Omédine., et al. "Combination of the Leaves of Annona muricata, Launaea taraxacifolia and Tridax procumbens: An Herbal Medicine for the Prevention and Treatment of Hypertension, Atherosclerosis and Cardiovascular Diseases". Acta Scientific Pharmaceutical Sciences 5.10 (2020): 02-08.

Copyright

Copyright: © 2021 Koukoui Omédine., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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