Anureet Kaur¹, Lakhvir Kaur¹*, Gurjeet Singh¹, RK Dhawan² and Ayushi Mahajan¹

¹Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India
²Department of Pharmacology, Khalsa College of Pharmacy, Amritsar, India

*Corresponding Author: Lakhvir Kaur, Department of Pharmaceutics, Khalsa College of Pharmacy, Amritsar, India.

Received: July 16, 2021; Published: August 31, 2021

Abstract

  The lyotropic liquid crystal are self-assembled mesophases that exhibit the properties of both crystalline solid and isotropic liquids. They can potentially deliver hydrophilic, lipophilic, amphiphilic molecules including proteins and peptides. The unique structure of liquid crystals facilitates the improved drug loading and controlled release of the drug. Liquid crystals are widely explored for topical delivery of drugs because of their strong bio-adhesive property and resemblance to the structure of the biological membrane when applied topically. The biological membrane like structure of LLC improves the skin retention and permeation of the drugs. Lyotropic liquid crystals are mainly classified into three main categories i.e., lamellar, hexagonal and cubic. The structural difference between various types of liquid crystals can be determined by using a number of characterization techniques such as transmission electron microscopy, small angle x-ray diffraction and polarized light microscopy. In this review, we have discussed the classification, preparation and characterization of liquid crystals along with their various therapeutic applications. We have discussed the potential effect of liquid crystals in brain targeting via intranasal route and its applications in targeting various types of tumour cells.

Keywords: Lyotropic Liquid Crystals; Cubosomes; Hexosomes; Transdermal Delivery; Brain Targeting; Tumour Targeting

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Citation

Citation: Lakhvir Kaur., et al. “Drug Delivery Via Lyotropic Liquid Crystals: An Innovative Approach". Acta Scientific Pharmaceutical Sciences 5.9 (2020): 94-101.

Copyright

Copyright: © 2020 Lakhvir Kaur., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.